Comparison of liver venous deprivation with portal vein embolization alone in patients undergoing major liver resection: a systematic review and meta-analysis

Abstract

Background

The clinical efficacy and safety between liver venous deprivation (LVD) and portal vein embolization (PVE) prior to major hepatectomy is still unclear.

Methods

Studies comparing LVD and PVE were obtained by systemically searching PubMed, Embase, and Cochrane Library Central databases through 22 December 2023.

Results

Ten studies including 588 patients were reviewed. Compared with PVE group, LVD group exhibited an increased liver resection rate (OR, 1.89; 95% CI, 1.13–3.15; P = 0.01), a faster KGR (MD, 1.37; 95% CI, 0.31–2.42; P = 0.01), and a shorter time to hepatectomy (MD, −6.66; 95% CI, −8.03 to −5.30; P < 0.0001). The pooled results showed that post-embolization complications (OR, 1.35; 95% CI, 0.66–2.74), overall postoperative complications (OR, 1.09; 95% CI, 0.68–1.75), severe complications (Clavien–Dindo ≥ III) (OR, 0.70; 95% CI, 0.43–1.14), and 90-day mortality (OR, 0.38; 95% CI, 0.13–1.09) were not significantly different in both groups. LVD group had significantly lower post-hepatectomy liver failure (PHLF) than PVE group (OR, 0.45; 95% CI, 0.22–0.91; P = 0.03).

Conclusion

LVD outperforms PVE regarding liver resection rate and future liver remnant (FLR) hypertrophy and shows comparable safety to PVE. In addition, LVD allowed for major hepatectomy with lower incidence of PHLF.