DNA methylation biomarkers for predicting lymph node metastasis in colorectal cancer.

IF 2.5 3区医学 Q2 ONCOLOGY Clinical & Translational Oncology Pub Date : 2025-02-01 Epub Date: 2024-07-18 DOI:10.1007/s12094-024-03601-6

Yu Sun, Deyang Kong, Qi Zhang, Renshen Xiang, Shuaibing Lu, Lin Feng, Haizeng Zhang

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Abstract

Colorectal cancer is one of the most common cancers worldwide. Lymph node metastasis is an important marker of colorectal cancer progression and plays a key role in the evaluation of patient prognosis. Accurate preoperative assessment of lymph node metastasis is crucial for devising appropriate treatment plans. However, current clinical imaging methods have limitations in many aspects. Therefore, the discovery of a method for accurately predicting lymph node metastasis is crucial clinical decision-making. DNA methylation is a common epigenetic modification that can regulate gene expression, which also has an important impact on the development of colorectal cancer. It is considered to be a promising biomarker with good specificity and stability and has promising application in predicting lymph node metastasis in patients with colorectal cancer. This article reviews the characteristics and limitations of currently available methods for predicting lymph node metastasis in patients with colorectal cancer and discusses the role of DNA methylation as a biomarker.

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预测结直肠癌淋巴结转移的 DNA 甲基化生物标志物。

结直肠癌是全球最常见的癌症之一。淋巴结转移是结直肠癌进展的重要标志，在评估患者预后方面起着关键作用。术前准确评估淋巴结转移对制定适当的治疗方案至关重要。然而，目前的临床成像方法在很多方面存在局限性。因此，发现一种能准确预测淋巴结转移的方法对临床决策至关重要。DNA 甲基化是一种常见的表观遗传修饰，可调控基因表达，对结直肠癌的发生发展也有重要影响。它被认为是一种具有良好特异性和稳定性的生物标志物，在预测结直肠癌患者淋巴结转移方面具有广阔的应用前景。本文回顾了目前可用来预测结直肠癌患者淋巴结转移的方法的特点和局限性，并讨论了 DNA 甲基化作为生物标记物的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical & Translational Oncology 医学-肿瘤学

CiteScore

6.20

自引率

2.90%

发文量

240

审稿时长

1 months

期刊介绍： Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of new targets for cancer therapy, and new technologies for research and treatment of cancer are the major themes covered by the educational series. Full research articles on a broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.