Crosstalk between gastrointestinal tract disorders and obstructive sleep apnea.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY Sleep and Breathing Pub Date : 2024-10-01 Epub Date: 2024-07-20 DOI:10.1007/s11325-024-03082-5

Shijie Jian, Jie Liu, Meng He, Bin Liu, Kun Liu, Chenyang Zang, Xiaoli Su, Yuan Zhang, Minhan Yi

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Abstract

Purpose: Clinical studies suggested associations between obstructive sleep apnea (OSA) and gastrointestinal tract disorders. This study aims to investigate the genetic causal relationship between OSA and gastrointestinal tract disorders, specifically gastroesophageal reflux disease (GERD) and inflammatory bowel disease (IBD).

Methods: In this study, we employed two-sample Mendelian Randomization (MR) analysis to investigate the potential relationships between OSA and GERD, and between OSA and IBD. More specifically, the primary analysis utilized inverse variance weighting (IVW). Weighted median, MR Egger, and MR PRESSO were applied to complicate potential violations of MR assumptions. Also, sensitivity analysis was evaluated and similar analysis was performed again after outliers were removed. Additionally, multivariable MR (MVMR) was conducted for associated pairs to adjust for obesity.

Results: Genetically predicted risk of GERD increased OSA risk by approximately 60% (OR_IVW = 1.62, 95%CI = [1.43,1.84]) which was also stable by other complicated approaches, and even with BMI adjusted by MVMR (OR_adjBMI[95%CI] = 1.26 [1.15,1.37]). Besides, OSA showed a mild causal effect on increased GERD risk after adjusting for obesity (OR_adjBMI[95%CI] = 1.05 [1.02,1.08]). Additionally, OSA increased the risks for IBD (OR_IVW[95%CI] = 1.36 [1.12,1.65]), including a higher risk of CD (OR_IVW[95%CI] = 1.41 [1.08,1.83]), and a trend for increasing UC risk (OR_IVW[95%CI] = 1.29 [0.99,1.67]).

Conclusion: GERD exerts a substantial causality on increasing the risk of OSA. Conversely, the potential for a causal relationship that OSA contributes to the development of GERD or IBD remains probable. These findings support the crosstalk between gastrointestinal tract disorders and OSA.

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胃肠道疾病与阻塞性睡眠呼吸暂停之间的相互影响。

目的：临床研究表明，阻塞性睡眠呼吸暂停（OSA）与胃肠道疾病之间存在关联。本研究旨在探讨 OSA 与胃肠道疾病（尤其是胃食管反流病和炎症性肠病）之间的遗传因果关系：在这项研究中，我们采用了双样本孟德尔随机分析法（MR）来研究 OSA 与胃食管反流病以及 OSA 与 IBD 之间的潜在关系。更具体地说，主要分析采用了反方差加权（IVW）。加权中位数、MR Egger 和 MR PRESSO 被用于使可能违反 MR 假设的情况复杂化。此外，还对敏感性分析进行了评估，并在剔除异常值后再次进行了类似分析。此外，还对相关配对进行了多变量 MR（MVMR）分析，以调整肥胖因素：结果：遗传预测的胃食管反流病风险使 OSA 风险增加了约 60%（ORIVW = 1.62，95%CI = [1.43,1.84]），其他复杂的方法也能稳定地预测这一风险，甚至经 MVMR 调整的 BMI 也能预测这一风险（ORadjBMI[95%CI] = 1.26 [1.15,1.37]）。此外，在对肥胖进行调整后，OSA 对胃食管反流病风险的增加显示出轻微的因果效应（ORadjBMI[95%CI] = 1.05 [1.02,1.08]）。此外，OSA 增加了 IBD 风险（ORIVW[95%CI] = 1.36 [1.12,1.65]），包括 CD 风险增加（ORIVW[95%CI] = 1.41 [1.08,1.83]）和 UC 风险增加趋势（ORIVW[95%CI] = 1.29 [0.99,1.67]）：结论：胃食管反流病对增加 OSA 风险有很大的因果关系。结论：胃食管反流病对增加 OSA 风险有很大的因果关系，相反，OSA 有可能导致胃食管反流病或肠道疾病的发生。这些研究结果支持胃肠道疾病与 OSA 之间的相互影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sleep and Breathing 医学-呼吸系统

CiteScore

5.20

自引率

4.00%

发文量

222

审稿时长

3-8 weeks

期刊介绍： The journal Sleep and Breathing aims to reflect the state of the art in the international science and practice of sleep medicine. The journal is based on the recognition that management of sleep disorders requires a multi-disciplinary approach and diverse perspectives. The initial focus of Sleep and Breathing is on timely and original studies that collect, intervene, or otherwise inform all clinicians and scientists in medicine, dentistry and oral surgery, otolaryngology, and epidemiology on the management of the upper airway during sleep. Furthermore, Sleep and Breathing endeavors to bring readers cutting edge information about all evolving aspects of common sleep disorders or disruptions, such as insomnia and shift work. The journal includes not only patient studies, but also studies that emphasize the principles of physiology and pathophysiology or illustrate potentially novel approaches to diagnosis and treatment. In addition, the journal features articles that describe patient-oriented and cost-benefit health outcomes research. Thus, with peer review by an international Editorial Board and prompt English-language publication, Sleep and Breathing provides rapid dissemination of clinical and clinically related scientific information. But it also does more: it is dedicated to making the most important developments in sleep disordered breathing easily accessible to clinicians who are treating sleep apnea by presenting well-chosen, well-written, and highly organized information that is useful for patient care.