Tryptophan and Its Derived Metabolites as Biomarkers for Tuberculosis Disease: A Systematic Review.

Q2 Biochemistry, Genetics and Molecular Biology Iranian Biomedical Journal Pub Date : 2024-06-29 DOI:10.61186/ibj.4174

Novi Maulina, Zinatul Hayati, Kartini Hasballah, Zulkarnain Zulkarnain

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Abstract

Feasible diagnostic assays are required to detect new TB cases and monitor treatment. This study aimed to evaluate evidence on Trp and its metabolites as proposed biomarkers for TB. Through specific keyword searches, we identified 170 relevant literature sources and included seven publications (from 2013 to 2023). The biomarker used in these studies were IDO activity, IDO-1 gene expression, and plasma IDO protein, measured using ELISA, LC-MS, UPLC, and transcriptional profiling. The studies encompassed a pediatric case-control and six studies involving adults, pregnant women with TB-HIV, and individuals with MDR-TB, active TB, and latent TB. The assessment of IDO activity and IDO protein level demonstrated promising performance in distinguishing active TB from controls and in evaluating treatment failure and recurrent cases to controls. Trp and its metabolites fulfilled nearly all of TPP criteria for detecting active TB. This study highlights the potential of utilizing host Trp and its metabolites as non-sputum-based biomarker for TB infection.

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色氨酸及其衍生代谢物作为结核病的生物标记物：系统综述。

需要可行的诊断方法来检测新的肺结核病例并监测治疗情况。本研究旨在评估将 Trp 及其代谢物作为肺结核生物标记物的证据。通过特定的关键词搜索，我们找到了 170 篇相关文献，其中包括 7 篇出版物（从 2013 年到 2023 年）。这些研究中使用的生物标记物是 IDO 活性、IDO-1 基因表达和血浆 IDO 蛋白，测量方法包括 ELISA、LC-MS、UPLC 和转录分析。这些研究包括一项儿科病例对照研究和六项涉及成人、结核病-艾滋病毒孕妇以及 MDR-结核病、活动性结核病和潜伏性结核病患者的研究。对 IDO 活性和 IDO 蛋白水平的评估表明，在区分活动性肺结核与对照组、评估治疗失败和复发病例与对照组方面，IDO 具有良好的表现。Trp 及其代谢物几乎符合 TPP 检测活动性肺结核的所有标准。这项研究凸显了利用宿主 Trp 及其代谢物作为结核病感染的非痰基生物标记物的潜力。

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