Emergence of monkeypox virus in central Argentina: Epidemiological features and first complete genome sequences in the country

IF 1.8 4区生物学 Q4 MICROBIOLOGY Revista Argentina de microbiologia Pub Date : 2024-07-01 DOI:10.1016/j.ram.2024.05.003

Gonzalo M. Castro , Paola E. Sicilia , Ana Willington , Laura López , Tomás Poklepovich , Josefina Campos , María G. Barbás

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Abstract

Monkeypox (Mpox) is a zoonotic disease caused by the monkeypox virus (MPXV). MPXV can be transmitted by close contact with lesions, body fluids, respiratory droplets, and contaminated materials. A new pattern of spread among sexual networks has been recently described. The present work aimed to report the epidemiological and genomic characterization of the 2022 MPXV outbreak in central Argentina. A total of 113 scabs and/or lesion swab specimens were studied. MPXV infection was confirmed in 46.0% of the studied patients, all of whom were men. Varicella-zoster virus infection was the most frequent differential diagnosis. Eight complete viral genomes were obtained by next-generation sequencing. The Argentinian sequences were grouped intermingled with other sequences from the 2022 MPXV outbreak, related to samples from the USA, Europe, and Peru. Taken together, our study provided an initial assessment of the genetic and epidemiological characteristics of the 2022 MPXV outbreak in Córdoba, Argentina.

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阿根廷中部出现猴痘病毒：流行病学特征和该国首个完整基因组序列。

猴痘（Mpox）是一种由猴痘病毒（MPXV）引起的人畜共患疾病。MPXV 可通过密切接触病灶、体液、呼吸道飞沫和受污染的材料传播。最近描述了一种在性网络中传播的新模式。本研究旨在报告 2022 年阿根廷中部爆发的 MPXV 流行病学和基因组特征。共研究了 113 份血痂和/或皮损拭子标本。46.0%的患者确诊感染了MPXV，所有患者均为男性。水痘-带状疱疹病毒感染是最常见的鉴别诊断。通过新一代测序获得了八个完整的病毒基因组。阿根廷的序列与 2022 年 MPXV 爆发时的其他序列混合在一起，这些序列与来自美国、欧洲和秘鲁的样本有关。综上所述，我们的研究初步评估了阿根廷科尔多瓦2022年MPXV疫情的遗传学和流行病学特征。

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来源期刊

Revista Argentina de microbiologia MICROBIOLOGY-

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： La Revista Argentina de Microbiología es una publicación trimestral editada por la Asociación Argentina de Microbiología y destinada a la difusión de trabajos científicos en las distintas áreas de la Microbiología. La Asociación Argentina de Microbiología se reserva los derechos de propiedad y reproducción del material aceptado y publicado.