Germline regulation of the somatic mitochondrial stress response.

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-08-01 Epub Date: 2024-07-20 DOI:10.1016/j.tcb.2024.07.004
Liankui Zhou, Ying Liu
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引用次数: 0

Abstract

Mitochondria are pivotal organelles for cellular energy production and the regulation of stress responses. Recent research has elucidated complex mechanisms through which mitochondrial stress in one tissue can impact distant tissues, thereby promoting overall organismal health. Two recent studies by Shen et al. and Charmpilas et al. have demonstrated that an intact germline serves as a crucial signaling hub for the activation of the somatic mitochondrial unfolded protein response (UPRmt) in Caenorhabditis elegans.

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种系对体细胞线粒体应激反应的调控。
线粒体是细胞产生能量和调节应激反应的关键细胞器。最近的研究阐明了一种复杂的机制,通过这种机制,一个组织中的线粒体应激可影响远处的组织,从而促进整个机体的健康。Shen 等人和 Charmpilas 等人最近的两项研究表明,完整的种系是激活草履虫体细胞线粒体未折叠蛋白反应(UPRmt)的关键信号枢纽。
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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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