Potential therapeutic properties of broccoli extract and soy isoflavones on improvement endometriosis and involved oxidative parameters.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-23 DOI:10.1515/hmbci-2023-0071

Soudabeh Sabetian, Parimah Archin Dialameh, Nader Tanideh, Behrooz Gharesifard, Moslem Ahmadi, Maryam Valibeigi, Perikala Vijayananda Kumar, Sarah Siahbani, Bahia Namavar Jahromi

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Abstract

Objectives: In Endometriosis is a gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity that is associated with chronic pelvic pain and subfertility. The purpose of the study was to investigate the effect of broccoli extract (BE) alone and in combination with soy isoflavones (SI) on endometrial implants in female rat.

Methods: In this study, endometriosis was induced surgically in 40 mature female rats. The rats were divided into 5 groups that were treated by oral gavage for 6 weeks with 0.5 mL of saline 0.9 %/day (control group), BE (3,000 mg/kg/day), SI (50 mg/kg/day), BE/soy isoflavones (BE 3000 mg/kg/day + soy isoflavones 50 mg/kg/day) and diphereline as a standard medication (3 mg/kg) intramuscularly. At the end of treatments, the volume and histopathology of the endometrial implants were compared among the 5 groups. The serum levels of oxidative parameters including superoxide dismutase (SOD), malondialdehyde (MDA) and tumor necrosis factor alpha (TNF-α) were also compared between the groups. The volume of the implants significantly decreased in diphereline group (p=0.002).

Results: The histopathological grade of endometrial implants in BE/SI and diphereline group were significantly decreased compared to the control group (p=0.001). The serum levels of SOD in BE group were enhanced significantly in comparison to the control group (p=0.034).

Conclusions: BE in combination with SI decreased the growth and histopathologic grades of transplanted endometrial implants. These herbal compounds may have the potential therapeutic effect to be used as an alternative medication for the treatment of endometriosis.

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西兰花提取物和大豆异黄酮对改善子宫内膜异位症和相关氧化参数的潜在治疗作用。

目的：子宫内膜异位症是一种以子宫内膜组织在子宫腔外生长为特征的妇科疾病，与慢性盆腔疼痛和不孕症有关。本研究旨在探讨西兰花提取物（BE）单独或与大豆异黄酮（SI）联合使用对雌性大鼠子宫内膜种植的影响：本研究通过手术诱导 40 只成熟雌性大鼠患上子宫内膜异位症。大鼠分为 5 组，分别口服 0.5 mL 生理盐水 0.9 %/天（对照组）、BE（3,000 mg/kg/天）、SI（50 mg/kg/天）、BE/大豆异黄酮（BE 3000 mg/kg/ 天 + 大豆异黄酮 50 mg/kg/天）和肌肉注射标准药物地匹林（3 mg/kg），治疗 6 周。治疗结束后，比较 5 组患者子宫内膜植入物的体积和组织病理学。此外，还比较了各组的血清氧化指标水平，包括超氧化物歧化酶（SOD）、丙二醛（MDA）和肿瘤坏死因子α（TNF-α）。结果显示，二苯醚组植入物的体积明显减少（P=0.002）：结果：与对照组相比，BE/SI 组和二磷酸盐组子宫内膜植入物的组织病理学分级明显降低（P=0.001）。结果：与对照组相比，BE/SI 组和地舍雷林组的子宫内膜植入物组织病理学分级明显降低（P=0.001）；与对照组相比，BE 组的血清 SOD 水平明显升高（P=0.034）：结论：BE 联合 SI 可减少移植子宫内膜植入物的生长和组织病理学分级。这些草药复合物可能具有潜在的治疗效果，可用作治疗子宫内膜异位症的替代药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.