Pregnancy after kidney and liver transplantation.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Samj South African Medical Journal Pub Date : 2024-04-24 DOI:10.7196/SAMJ.2024.v114i3b.1240

A Wise, N E Diana, B Bobat, R T Saggers, S Bhoora, S Budhram, L Chauke, V G Lala, A Mahomed, D Mokgoko, M Seabi, B Moore, S Naidoo, R B Nyakoe, N Odell, G Paget, L Wium, J Zamparini

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Abstract

Pregnancy in kidney and liver transplant recipients presents unique challenges and risks for both maternal and fetal health. This article examines the management of pregnancy in kidney and liver transplant recipients, focusing on pre-pregnancy counselling, trimester-specific care, the teratogenic effects of immunosuppressive drugs, and the role of the multidisciplinary team. While South African (SA) data on this topic are limited, the Transplant Pregnancy Registry International has provided valuable insights. Despite the increased risk of maternal and fetal complications, the overall risk of graft loss during pregnancy is low. Graft survival rates are comparable between pregnant and non- pregnant transplant recipients, except for pregnancies occurring within 1 year of transplantation. By addressing the complexities of managing pregnant women with kidney or liver transplants, this article underscores the importance of tailored care and the involvement of various medical specialists. It also explores the safety of and potential complications associated with specific immunosuppressive therapies during pregnancy. Further research is needed to enhance our understanding and optimise the management of these high-risk pregnancies in SA.

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肾移植和肝移植后的妊娠。

肝肾移植受者妊娠对母体和胎儿的健康都带来了独特的挑战和风险。本文探讨了肾移植和肝移植受者的妊娠管理，重点关注孕前咨询、特定孕期的护理、免疫抑制剂的致畸作用以及多学科团队的作用。虽然南非在这方面的数据有限，但国际移植妊娠登记处提供了宝贵的见解。尽管母体和胎儿并发症的风险增加，但妊娠期移植物丢失的总体风险很低。除移植后一年内怀孕的受者外，怀孕和未怀孕的移植受者的移植物存活率相当。本文探讨了管理接受肾脏或肝脏移植的孕妇的复杂性，强调了量身定制的护理和各种医疗专家参与的重要性。文章还探讨了妊娠期特定免疫抑制疗法的安全性和潜在并发症。我们需要进一步开展研究，以加深了解并优化对南澳州高危妊娠的管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Samj South African Medical Journal 医学-医学：内科

CiteScore

3.00

自引率

4.50%

发文量

175

审稿时长

4-8 weeks

期刊介绍： The SAMJ is a monthly peer reviewed, internationally indexed, general medical journal. It carries The SAMJ is a monthly, peer-reviewed, internationally indexed, general medical journal publishing leading research impacting clinical care in Africa. The Journal is not limited to articles that have ‘general medical content’, but is intending to capture the spectrum of medical and health sciences, grouped by relevance to the country’s burden of disease. This will include research in the social sciences and economics that is relevant to the medical issues around our burden of disease The journal carries research articles and letters, editorials, clinical practice and other medical articles and personal opinion, South African health-related news, obituaries, general correspondence, and classified advertisements (refer to the section policies for further information).