An Overview of the Natural Neuroprotective Agents for the Management of Cognitive Impairment Induced by Scopolamine in Zebrafish (Danio rerio).

Sara Abidar, Lucian Hritcu, Mohamed Nhiri
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Abstract

Alzheimer's Disease (AD) is a neurodegenerative disorder mainly characterized by dementia and cognitive decline. AD is essentially associated with the presence of aggregates of the amyloid-β peptide and the hyperphosphorylated microtubule-associated protein tau. The available AD therapies can only alleviate the symptoms; therefore, the development of natural treatments that exhibit neuroprotective effects and correct the behavioral impairment is a critical requirement. The present review aims to collect the natural substances that have been evaluated for their neuroprotective profile against AD-like behaviors induced in zebrafish (Danio rerio) by scopolamine. We focused on articles retrieved from the PubMed database via preset searching strings from 2010 to 2023. Our review assembled 21 studies that elucidated the activities of 28 various natural substances, including bioactive compounds, extracts, fractions, commercial compounds, and essential oils. The listed compounds enhanced cognition and showed several mechanisms of action, namely antioxidant potential, acetylcholinesterase's inhibition, and reduction of lipid peroxidation. Additional studies should be achieved to demonstrate their preventive and therapeutic activities in cellular and rodent models. Further clinical trials would be extremely solicited to support more insight into the neuroprotective effects of the most promising drugs in an AD context.

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管理东莨菪碱诱导的斑马鱼(Danio rerio)认知障碍的天然神经保护剂概述。
阿尔茨海默病(AD)是一种以痴呆和认知能力下降为主要特征的神经退行性疾病。阿尔茨海默病主要与淀粉样蛋白-β肽和高磷酸化微管相关蛋白 tau 的聚集有关。现有的注意力缺失症疗法只能缓解症状,因此,开发具有神经保护作用和纠正行为障碍的天然疗法至关重要。本综述旨在收集针对东莨菪碱诱导斑马鱼(Danio rerio)出现类似 AD 行为的神经保护作用进行过评估的天然物质。我们重点关注了 2010 年至 2023 年期间通过预设搜索字符串从 PubMed 数据库检索到的文章。我们的综述汇集了 21 项研究,阐明了 28 种天然物质的活性,包括生物活性化合物、提取物、馏分、商业化合物和精油。所列化合物可增强认知能力,并显示出多种作用机制,即抗氧化潜力、乙酰胆碱酯酶抑制作用和减少脂质过氧化作用。应开展更多的研究,在细胞和啮齿动物模型中证明这些化合物的预防和治疗作用。此外,还需要进行更多的临床试验,以便更深入地了解最有前景的药物在注意力缺失症中的神经保护作用。
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