Effect of Replacing Sucrose in Beverages with Nonnutritive Sweetener Sucralose on Cardiometabolic Risk Factors Among Asian Indian Adults with Type 2 Diabetes: A 12-Week Randomized Controlled Trial.

IF 3.8 3区医学 Q2 Medicine Diabetes Therapy Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI:10.1007/s13300-024-01622-6

Viswanathan Mohan, Valangaiman Sriram Manasa, Kuzhandaivelu Abirami, Ranjit Unnikrishnan, Rajagopal Gayathri, Gunasekaran Geetha, Mookambika RamyaBai, Soundararajan Padmavathi, Marimuthu Rajalakshmi, Rajendra Pradeepa, Ranjit Mohan Anjana, Kamala Krishnaswamy, Vasudevan Sudha

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Abstract

Introduction: Country-specific evidence-based research is crucial for understanding the role of nonnutritive sweeteners (NNS) in managing type 2 diabetes (T2D). The main aim of this study was to explore the effect of replacing sucrose with sucralose in coffee/tea in Asian Indians with type 2 diabetes (T2D).

Methods: This 12-week, parallel-arm randomized controlled trial included 210 participants with T2D, assigned to the intervention group, where sugar/sucrose in coffee or tea was substituted with sucralose, or the control group, where sugar/sucrose was continued. Lifestyle factors remained unchanged. The primary outcome was change in HbA1c. Secondary outcomes were changes in body weight (BW), body mass index (BMI), waist circumference (WC), lipid profiles, and inflammatory markers.

Results: At the end of 12 weeks, no change was observed in HbA1c, fasting plasma glucose, lipid profile, and inflammatory markers between or within groups. There was a small but significant reduction in BW (- 0.5 kg [95% CI - 1.0, - 0.1]; p = 0.02), BMI (- 0.2 kg/m² [- 0.4, 0.0]; p = 0.03), and WC (- 0.8 cm [- 1.4, - 0.3]; p = 0.002) in the intervention group. Improvements were also observed in lipid accumulation product (p = 0.01), visceral adiposity index (p = 0.04), triglyceride/glucose index (p = 0.04), total energy intake (p = 0.04), and carbohydrate intake (p < 0.0001).

Conclusions: In Asian Indians with T2D, replacing about 60 kcal of added sucrose with sucralose in coffee/ tea had no benefit on glycemia but resulted in a small reduction in body weight, body mass index, and waist circumference.

Trial registration: Clinical Trials Registry of India (CTRI/2021/04/032686).

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用非营养性甜味剂三氯蔗糖替代饮料中的蔗糖对患有 2 型糖尿病的亚裔印度成年人心脏代谢风险因素的影响：一项为期 12 周的随机对照试验。

导言：针对具体国家的循证研究对于了解非营养型甜味剂（NNS）在控制 2 型糖尿病（T2D）中的作用至关重要。本研究的主要目的是探讨在亚洲印度裔 2 型糖尿病患者的咖啡/茶中用蔗糖素(三氯蔗糖)替代蔗糖的效果：这项为期 12 周的平行臂随机对照试验包括 210 名 2 型糖尿病患者，他们被分配到干预组（用蔗糖素(三氯蔗糖)替代咖啡或茶中的糖/蔗糖）或对照组（继续使用糖/蔗糖）。生活方式因素保持不变。主要结果是 HbA1c 的变化。次要结果是体重（BW）、体重指数（BMI）、腰围（WC）、血脂概况和炎症指标的变化：结果：12 周结束时，组间和组内的 HbA1c、空腹血浆葡萄糖、血脂和炎症指标均无变化。干预组的体重（- 0.5 kg [95% CI - 1.0, - 0.1]；p = 0.02）、体重指数（- 0.2 kg/m2 [- 0.4, 0.0]；p = 0.03）和腹围（- 0.8 cm [- 1.4, - 0.3]；p = 0.002）有小幅但显著的下降。此外，还观察到干预组的脂质堆积产物（p = 0.01）、内脏脂肪指数（p = 0.04）、甘油三酯/葡萄糖指数（p = 0.04）、总能量摄入量（p = 0.04）和碳水化合物摄入量（p 结论：干预组的脂质堆积产物、内脏脂肪指数、甘油三酯/葡萄糖指数和碳水化合物摄入量均有所改善：在患有 T2D 的亚洲印度人中，用蔗糖素(三氯蔗糖)取代咖啡/茶中约 60 千卡的添加蔗糖对血糖无益，但可使体重、体重指数和腰围略有下降：试验登记：印度临床试验登记处（CTRI/2021/04/032686）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.