Evaluation of potential punishing effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in rhesus monkeys responding under a choice procedure.

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES Behavioural Pharmacology Pub Date : 2024-10-01 Epub Date: 2024-07-17 DOI:10.1097/FBP.0000000000000787

David R Maguire

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Abstract

Objectives: There has been substantial and growing interest in the therapeutic utility of drugs acting at serotonin 2A subtype (5-HT 2A ) receptors, increasing the need for characterization of potential beneficial and adverse effects of such compounds. Although numerous studies have evaluated the possible rewarding and reinforcing effects of 5-HT 2A receptor agonists, there have been relatively few studies on potential aversive effects.

Methods: The current study investigated punishing effects of 2,5-dimethoxy-4-methylamphetamine (DOM) in four rhesus monkeys responding under a choice procedure in which responding on one lever delivered a sucrose pellet alone and responding on the other lever delivered a sucrose pellet plus an intravenous infusion of a range of doses of fentanyl (0.1-3.2 µg/kg/infusion), histamine (3.2-100 µg/kg/infusion), or DOM (3.2-100 µg/kg/infusion).

Results: When fentanyl was available, responding for a pellet plus an infusion increased dose dependently in all subjects, indicating a positive reinforcing effect of fentanyl. When histamine was available, responding for a pellet plus an infusion decreased in three of four subjects, indicating a punishing effect of histamine. Whether available before or after histamine, DOM did not systematically alter choice across the range of doses tested.

Conclusion: These results suggest that the 5-HT 2A receptor agonist DOM has neither positive reinforcing nor punishing effects under a choice procedure that is sensitive to both processes.

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评估 2,5-二甲氧基-4-甲基苯丙胺（DOM）对在选择程序下做出反应的恒河猴的潜在惩罚效应。

研究目的人们对作用于血清素 2A 亚型（5-HT2A）受体的药物的治疗作用产生了浓厚的兴趣，而且这种兴趣还在不断增长。尽管已有大量研究评估了 5-HT2A 受体激动剂可能产生的奖赏和强化作用，但有关潜在厌恶作用的研究却相对较少：本研究调查了 2,5-二甲氧基-4-甲基苯丙胺（DOM）对四只恒河猴的惩罚效应，在选择过程中，在一个杠杆上做出反应会得到一个蔗糖颗粒，而在另一个杠杆上做出反应会得到一个蔗糖颗粒，同时静脉注射一定剂量的芬太尼（0.1-3.2微克/千克/输注）、组胺（3.2-100微克/千克/输注）或DOM（3.2-100微克/千克/输注）：当提供芬太尼时，所有受试者对颗粒和输液的反应均随剂量增加而增加，这表明芬太尼具有正强化作用。当组胺可用时，四名受试者中有三人对颗粒和输液的反应减少，这表明组胺具有惩罚作用。无论是在组胺之前还是之后提供 DOM，在测试的剂量范围内都不会系统性地改变选择：这些结果表明，在对5-HT2A受体激动剂和组胺都敏感的选择过程中，5-HT2A受体激动剂DOM既没有正强化作用，也没有惩罚作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.