Antioxidant activity of polysaccharide from Garcinia mangostana rind and their derivatives.

IF 3.4 2区医学 Q1 INTEGRATIVE & COMPLEMENTARY MEDICINE BMC Complementary Medicine and Therapies Pub Date : 2024-07-25 DOI:10.1186/s12906-024-04594-z

Zhenjie Tang, Gangliang Huang

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Abstract

Background: Polysaccharide from Garcinia mangostana rind has many biological activities and deserves further research.

Methods: The antioxidant properties of UAEE-GMRP, UAEE-GMRP-1 A, CM-30, and Ac-30 were evaluated through two different antioxidant activity experimental systems.

Results: The four polysaccharides had a better scavenging effect on hydroxyl radicals, while their inhibitory effect on lipid peroxidation was relatively weak. However, overall, the four polysaccharides showed a certain degree of potential application in the two antioxidant experiments mentioned above, especially the chemically modified polysaccharides from Garcinia mangostana rind, which effectively improved their antioxidant activity. This also indicates that chemical modification is a better method to improve polysaccharide activity. In addition, in these two antioxidant exploration experiments, carboxymethylated polysaccharide showed stronger activity compared to the other three polysaccharides.

Conclusion: The carboxymethylation modification may have great potential for application.

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藤黄果皮多糖及其衍生物的抗氧化活性

背景从藤黄果皮中提取的多糖具有多种生物活性，值得进一步研究：方法：通过两种不同的抗氧化活性实验体系，评估了 UAEE-GMRP、UAEE-GMRP-1 A、CM-30 和 Ac-30 的抗氧化性：结果：四种多糖对羟自由基有较好的清除作用，而对脂质过氧化的抑制作用相对较弱。但总的来说，这四种多糖在上述两个抗氧化实验中表现出了一定的应用潜力，尤其是经过化学修饰的藤黄果皮多糖，有效提高了其抗氧化活性。这也说明化学修饰是提高多糖活性的较好方法。此外，在这两项抗氧化探索实验中，羧甲基化多糖与其他三种多糖相比表现出更强的活性：结论：羧甲基化改性具有很大的应用潜力。

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