Strain-dependent variations in replication of European clade 2.3.4.4b influenza A(H5N1) viruses in bovine cells and thermal inactivation in semi-skimmed or whole milk.

IF 9.9 2区 医学 Q1 INFECTIOUS DISEASES Eurosurveillance Pub Date : 2024-07-01 DOI:10.2807/1560-7917.ES.2024.29.30.2400436
Diana I Palme, Juliane Lang, Dajana Helke, Maryna Kuryshko, Elsayed M Abdelwhab
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Abstract

We investigated the thermostability of four European avian influenza A(H5N1) viruses in whole and semi-skimmed milk and their replication in bovine kidney and lung cells amid the current influenza A(H5N1) dairy cattle outbreak in the United States. Results showed strain-dependent differences in thermal inactivation, particularly in whole milk, and variable replication efficacy in lung cells. These findings support assessing the inactivation of European H5N1 viruses in milk and their replication in bovine cells, aiding biosafety protocols and public health measures.

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欧洲 2.3.4.4b 支系甲型 H5N1 流感病毒在牛细胞中复制和在半脱脂奶或全脂奶中热灭活的菌株依赖性变化。
在美国目前爆发的甲型 H5N1 奶牛流感疫情中,我们研究了四种欧洲甲型 H5N1 禽流感病毒在全脂奶和半脱脂奶中的热稳定性及其在牛肾细胞和肺细胞中的复制情况。结果表明,热灭活(尤其是全脂牛奶中的热灭活)和在肺细胞中的复制效果因菌株而异。这些发现支持对牛奶中欧洲 H5N1 病毒的灭活及其在牛细胞中的复制进行评估,从而有助于生物安全协议和公共卫生措施的制定。
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来源期刊
Eurosurveillance
Eurosurveillance INFECTIOUS DISEASES-
CiteScore
32.70
自引率
2.10%
发文量
430
审稿时长
3-8 weeks
期刊介绍: Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.
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