Collagen as the extracellular matrix biomaterials in the arena of medical sciences

IF 2.5 4区生物学 Q1 ANATOMY & MORPHOLOGY Tissue & cell Pub Date : 2024-10-01 Epub Date: 2024-07-24 DOI:10.1016/j.tice.2024.102497

Ramachandregowda Sowbhagya , Harsha Muktha , Thippenahalli Narasimhaiah Ramakrishnaiah , Adagur Sudarshan Surendra , Subhas Madinoor Sushma , Chandrashekar Tejaswini , Karunakaran Roopini , Somashekara Rajashekara

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Abstract

Collagen is a multipurpose material that has several applications in the health care, dental care, and pharmaceutical industries. Crosslinked compacted solids or lattice-like gels can be made from collagen. Biocompatibility, biodegradability, and wound-healing properties make collagen a popular scaffold material for cardiovascular, dentistry, and bone tissue engineering. Due to its essential role in the control of several of these processes, collagen has been employed as a wound-healing adjunct. It forms a major component of the extracellular matrix and regulates wound healing in its fibrillar or soluble forms. Collagen supports cardiovascular and other soft tissues. Oral wounds have been dressed with resorbable forms of collagen for closure of graft and extraction sites, and to aid healing. This present review is concentrated on the use of collagen in bone regeneration, wound healing, cardiovascular tissue engineering, and dentistry.

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胶原蛋白是医学领域的细胞外基质生物材料。

胶原蛋白是一种多用途材料，在保健、牙科护理和制药行业有多种应用。胶原蛋白可制成交联密实固体或晶格状凝胶。胶原蛋白的生物相容性、生物可降解性和伤口愈合特性使其成为心血管、牙科和骨组织工程领域最受欢迎的支架材料。由于胶原蛋白在控制上述几个过程中起着至关重要的作用，因此已被用作伤口愈合的辅助材料。胶原蛋白是细胞外基质的主要成分，以纤维状或可溶性形式调节伤口愈合。胶原蛋白对心血管和其他软组织具有支撑作用。口腔伤口已用可吸收形式的胶原蛋白包扎，以封闭移植和拔牙部位，并帮助伤口愈合。本综述主要介绍胶原蛋白在骨再生、伤口愈合、心血管组织工程和牙科中的应用。

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来源期刊

Tissue & cell 医学-解剖学与形态学

CiteScore

3.90

自引率

0.00%

发文量

234

期刊介绍： Tissue and Cell is devoted to original research on the organization of cells, subcellular and extracellular components at all levels, including the grouping and interrelations of cells in tissues and organs. The journal encourages submission of ultrastructural studies that provide novel insights into structure, function and physiology of cells and tissues, in health and disease. Bioengineering and stem cells studies focused on the description of morphological and/or histological data are also welcomed. Studies investigating the effect of compounds and/or substances on structure of cells and tissues are generally outside the scope of this journal. For consideration, studies should contain a clear rationale on the use of (a) given substance(s), have a compelling morphological and structural focus and present novel incremental findings from previous literature.