Effect of Jiedu Huayu decoction on oral mucosal Axin and β-catenin expression in oral submucosal fibrosis model rats.

Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan Pub Date : 2024-08-01 DOI:10.19852/j.cnki.jtcm.20240617.001

Zhu Xuan, Lou An, Zhu Keke, Ruan Mingyu

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Abstract

Objective: To investigate the protective effect of the Chinese herbal formula of Jiedu Huayu decoction (, JHD) on oral mucosa of rats with oral submucosal fibrosis (OSF) and its potential mechanism of action.

Methods: Sprague-Dawley male OSF model rats were constructed by injection of betaine and topical rubbing and were randomly grouped and administered by gavage for 4 weeks. Mouth opening and buccal mucosa scores interleukin levels and the expression of Axin and β-catenin proteins or genes were measured before and after drug administration.

Results: After treatment with JHD the buccal mucosal lesions of rats were significantly reduced Axin protein and mRNA expression were significantly increased β-catenin protein and mRNA expression were significantly decreased interleukin-1β and interleukin-6 levels were decreased and interleukin-10 levels were increased.

Conclusion: The mechanism of action of JHD can effectively alleviate the pathological damage of buccal mucosa in OSF rats which may be related to the promotion of Axin expression and inhibition of β-catenin expression.

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解毒化瘀汤对口腔黏膜下纤维化模型大鼠口腔黏膜Axin和β-catenin表达的影响

目的研究中药方剂解毒化瘀汤对口腔黏膜下纤维化（OSF）大鼠口腔黏膜的保护作用及其潜在作用机制：方法：通过注射甜菜碱和局部涂抹建立Sprague-Dawley雄性OSF模型大鼠，随机分组，灌胃给药4周。在用药前后测量张口和颊粘膜评分白细胞介素水平、Axin和β-catenin蛋白或基因的表达：结果：用JHD治疗后，大鼠口腔黏膜病变明显减轻，Axin蛋白和mRNA表达明显增加，β-catenin蛋白和mRNA表达明显减少，白细胞介素-1β和白细胞介素-6水平降低，白细胞介素-10水平升高：JHD能有效缓解OSF大鼠口腔黏膜的病理损伤，其作用机制可能与促进Axin表达和抑制β-catenin表达有关。

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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

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