Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline

IF 1.2 4区化学 Q4 CHEMISTRY, INORGANIC & NUCLEAR Journal of Structural Chemistry Pub Date : 2024-07-26 DOI:10.1134/S0022476624070175

P. E. Savinykh, Y. A. Golubeva, K. S. Smirnova, L. S. Klyushova, M. P. Davydova, A. V. Artemiev, E. V. Lider

{"title":"Synthesis and Structure of Cytotoxic Copper(II) Complexes Based on di(o-tolyl)Phosphinic Acid and 2,2'-Bipyridine/1,10-Phenanthroline","authors":"P. E. Savinykh, Y. A. Golubeva, K. S. Smirnova, L. S. Klyushova, M. P. Davydova, A. V. Artemiev, E. V. Lider","doi":"10.1134/S0022476624070175","DOIUrl":null,"url":null,"abstract":"The following series of copper(II) complexes based on di(o-tolyl)phosphinic acid (HL) and 1,10-phenanthroline (phen), 5-chloro-1,10-phenanthroline (Cl-phen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 2,2′-bipyridine (bipy) is prepared and characterized: [Cu(OH)L]n (1), [Cu(phen)(H2O)L2] (2), [Cu(dmphen)(H2O)L2] (3), [Cu(Cl-phen)(H2O)L2] (4), [Cu(bipy)(H2O)L2] (5). According to the XRD data, the phosphinate anion L– exhibits a monodentate coordination in mononuclear complexes 2–5 and a bidentate-bridge coordination in the polymer complex 1. The cytotoxic activity of the ligands and complexes is studied using the A549 (carcinoma) and MRC5 (non-neoplastic fibroblasts) human lung cell lines. It is shown that the complexes exhibit pronounced dose-dependent cytotoxicity to these cell lines in the 1-50 µM concentration range.","PeriodicalId":668,"journal":{"name":"Journal of Structural Chemistry","volume":"65 7","pages":"1465 - 1476"},"PeriodicalIF":1.2000,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Structural Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S0022476624070175","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}

引用次数: 0

Abstract

The following series of copper(II) complexes based on di(o-tolyl)phosphinic acid (HL) and 1,10-phenanthroline (phen), 5-chloro-1,10-phenanthroline (Cl-phen), 4,7-dimethyl-1,10-phenanthroline (dmphen), 2,2′-bipyridine (bipy) is prepared and characterized: [Cu(OH)L]_n (1), [Cu(phen)(H₂O)L₂] (2), [Cu(dmphen)(H₂O)L₂] (3), [Cu(Cl-phen)(H₂O)L₂] (4), [Cu(bipy)(H₂O)L₂] (5). According to the XRD data, the phosphinate anion L^– exhibits a monodentate coordination in mononuclear complexes 2–5 and a bidentate-bridge coordination in the polymer complex 1. The cytotoxic activity of the ligands and complexes is studied using the A549 (carcinoma) and MRC5 (non-neoplastic fibroblasts) human lung cell lines. It is shown that the complexes exhibit pronounced dose-dependent cytotoxicity to these cell lines in the 1-50 µM concentration range.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

基于二（邻甲苯基）膦酸和 2,2'-联吡啶/1,10-菲罗啉的细胞毒性铜（II）配合物的合成及其结构

摘要以二(邻甲苯基)膦酸(HL)和1,10-菲罗啉(phen)、5-氯-1,10-菲罗啉(Cl-phen)、4,7-二甲基-1,10-菲罗啉(dmphen)、2,2′-联吡啶(bipy)为基础，制备并表征了以下系列铜(II)配合物：[Cu(OH)L]n (1)、[Cu(phen)(H2O)L2] (2)、[Cu(dmphen)(H2O)L2] (3)、[Cu(Cl-phen)(H2O)L2] (4)、[Cu(bipy)(H2O)L2] (5)。根据 XRD 数据，膦酸阴离子 L- 在单核络合物 2-5 中呈现单齿配位，在聚合物络合物 1 中呈现双齿桥配位。利用 A549（癌细胞）和 MRC5（非肿瘤性成纤维细胞）人肺细胞系研究了配体和复合物的细胞毒性活性。研究表明，在 1-50 µM 的浓度范围内，这些复合物对这些细胞株具有明显的剂量依赖性细胞毒性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Journal of Structural Chemistry 化学-无机化学与核化学

CiteScore

1.60

自引率

12.50%

发文量

142

审稿时长

8.3 months

期刊介绍： Journal is an interdisciplinary publication covering all aspects of structural chemistry, including the theory of molecular structure and chemical bond; the use of physical methods to study the electronic and spatial structure of chemical species; structural features of liquids, solutions, surfaces, supramolecular systems, nano- and solid materials; and the crystal structure of solids.