Epigenetic clocks and gliomas: unveiling the molecular interactions between aging and tumor development

IF 3.9 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Frontiers in Molecular Biosciences Pub Date : 2024-07-26 DOI:10.3389/fmolb.2024.1446428

Shiliang Chen, Yi Jiang, Cong Wang, Shiyuan Tong, Yibo He, Wenqiang Lu, Zhezhong Zhang

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Abstract

Gliomas, the most prevalent and aggressive primary brain tumors, represent a diverse group of malignancies originating from glial cells. These tumors account for significant brain tumor-related morbidity and mortality, with higher incidence rates in North America and Europe compared to Asia and Africa. Genetic predispositions and environmental factors, particularly ionizing radiation, critically impact glioma risk. Epigenetics, particularly DNA methylation, plays a pivotal role in glioma research, with IDH-mutant gliomas showing aberrant methylation patterns contributing to tumorigenesis. Epigenetic clocks, biomarkers based on DNA methylation patterns predicting biological age, have revealed significant insights into aging and tumor development. Recent studies demonstrate accelerated epigenetic aging in gliomas, correlating with increased cancer risk and poorer outcomes. This review explores the mechanisms of epigenetic clocks, their biological significance, and their application in glioma research. Furthermore, the clinical implications of epigenetic clocks in diagnosing, prognosticating, and treating gliomas are discussed. The integration of epigenetic clock data into personalized medicine approaches holds promise for enhancing therapeutic strategies and patient outcomes in glioma treatment.

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表观遗传时钟与胶质瘤：揭示衰老与肿瘤发生之间的分子相互作用

胶质瘤是最常见和最具侵袭性的原发性脑肿瘤，是一组源自神经胶质细胞的多种恶性肿瘤。这些肿瘤导致了大量与脑肿瘤相关的发病率和死亡率，与亚洲和非洲相比，北美和欧洲的发病率更高。遗传易感性和环境因素，尤其是电离辐射，对胶质瘤的风险有着至关重要的影响。表观遗传学，尤其是 DNA 甲基化，在胶质瘤研究中起着举足轻重的作用，IDH 突变胶质瘤显示出异常的甲基化模式，导致肿瘤发生。表观遗传时钟是基于 DNA 甲基化模式预测生物年龄的生物标记，它揭示了衰老和肿瘤发生的重要规律。最近的研究表明，胶质瘤的表观遗传老化加速，与癌症风险增加和预后较差相关。本综述探讨了表观遗传时钟的机制、其生物学意义及其在胶质瘤研究中的应用。此外，还讨论了表观遗传时钟在胶质瘤诊断、预后和治疗中的临床意义。将表观遗传时钟数据整合到个性化医疗方法中，有望改善胶质瘤的治疗策略和患者预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Molecular Biosciences Biochemistry, Genetics and Molecular Biology-Biochemistry

CiteScore

7.20

自引率

4.00%

发文量

1361

审稿时长

14 weeks

期刊介绍： Much of contemporary investigation in the life sciences is devoted to the molecular-scale understanding of the relationships between genes and the environment — in particular, dynamic alterations in the levels, modifications, and interactions of cellular effectors, including proteins. Frontiers in Molecular Biosciences offers an international publication platform for basic as well as applied research; we encourage contributions spanning both established and emerging areas of biology. To this end, the journal draws from empirical disciplines such as structural biology, enzymology, biochemistry, and biophysics, capitalizing as well on the technological advancements that have enabled metabolomics and proteomics measurements in massively parallel throughput, and the development of robust and innovative computational biology strategies. We also recognize influences from medicine and technology, welcoming studies in molecular genetics, molecular diagnostics and therapeutics, and nanotechnology. Our ultimate objective is the comprehensive illustration of the molecular mechanisms regulating proteins, nucleic acids, carbohydrates, lipids, and small metabolites in organisms across all branches of life. In addition to interesting new findings, techniques, and applications, Frontiers in Molecular Biosciences will consider new testable hypotheses to inspire different perspectives and stimulate scientific dialogue. The integration of in silico, in vitro, and in vivo approaches will benefit endeavors across all domains of the life sciences.