Neuroprotective Efficacy and Complementary Treatment with Medicinal Herbs: A Comprehensive Review of Recent Therapeutic Approaches in Epilepsy Management.

Amit Anand, Aman Shrivastava, Kuldeep Singh, Rakesh Barik, Devshree Gayakwad, Jailani S, Shamim, Sumeet Dwivedi
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Abstract

Central Nervous System (CNS) disorders affect millions of people worldwide, with a significant proportion experiencing drug-resistant forms where conventional medications fail to provide adequate seizure control. This abstract delves into recent advancements and innovative therapies aimed at addressing the complex challenge of CNS-related drug-resistant epilepsy (DRE) management. The idea of precision medicine has opened up new avenues for epilepsy treatment. Herbs such as curcumin, ginkgo biloba, panax ginseng, bacopa monnieri, ashwagandha, and rhodiola rosea influence the BDNF pathway through various mechanisms. These include the activation of CREB, inhibition of NF-κB, modulation of neurotransmitters, reduction of oxidative stress, and anti- inflammatory effects. By promoting BDNF expression and activity, these herbs support neuroplasticity, cognitive function, and overall neuronal health. Novel antiepileptic drugs (AEDs) with distinct mechanisms of action demonstrate efficacy in refractory cases where traditional medications falter. Additionally, repurposing existing drugs for antiepileptic purposes presents a cost-effective strategy to broaden therapeutic choices. Cannabidiol (CBD), derived from cannabis herbs, has garnered attention for its anticonvulsant properties, offering a potential adjunctive therapy for refractory seizures. In conclusion, recent advances and innovative therapies represent a multifaceted approach to managing drug-resistant epilepsy. Leveraging precision medicine, neurostimulation technologies, novel pharmaceuticals, and complementary therapies, clinicians can optimize treatment outcomes and improve the life expectancy of patients living with refractory seizures. Genetic testing and biomarker identification now allow for personalized therapeutic approaches tailored to individual patient profiles. Utilizing next-generation sequencing techniques, researchers have elucidated genetic mutations.

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神经保护功效与药草辅助治疗:最新癫痫治疗方法综述》。
中枢神经系统(CNS)疾病影响着全球数百万人,其中相当一部分人具有耐药性,传统药物无法充分控制癫痫发作。本摘要深入探讨了旨在应对中枢神经系统相关耐药癫痫(DRE)管理这一复杂挑战的最新进展和创新疗法。精准医疗的理念为癫痫治疗开辟了新途径。姜黄素、银杏叶、三七、百部、灰树叶和红景天等草药通过各种机制影响 BDNF 通路。这些机制包括激活 CREB、抑制 NF-κB、调节神经递质、减少氧化应激和抗炎作用。通过促进 BDNF 的表达和活性,这些草药有助于神经可塑性、认知功能和整体神经元健康。新型抗癫痫药物(AEDs)具有独特的作用机制,对传统药物难以奏效的难治性病例具有疗效。此外,将现有药物重新用于抗癫痫目的也是一种具有成本效益的策略,可扩大治疗选择范围。从大麻药草中提取的大麻二酚(CBD)因其抗惊厥特性而备受关注,为难治性癫痫发作提供了一种潜在的辅助疗法。总之,最新进展和创新疗法代表了一种管理耐药性癫痫的多方面方法。利用精准医疗、神经刺激技术、新型药物和辅助疗法,临床医生可以优化治疗效果,改善难治性癫痫发作患者的预期寿命。通过基因检测和生物标记物鉴定,现在可以根据患者的个体情况采取个性化的治疗方法。利用新一代测序技术,研究人员已经阐明了基因突变。
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