Namyoung Park, Jae Min Lee, Jin Myung Park, Sang Hyub Lee, Kyung-Do Han, Kwang Ro Joo, Ji Kon Ryu, Yong-Tae Kim
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引用次数: 0
Abstract
Objectives: This study aimed to identify the risk factors for acute pancreatitis (AP) in young adults in their 20s based on data from the nationwide cohort in South Korea.
Materials and methods: From the 2009 national health examination database of South Korea, a total of 471,098 individuals between the ages of 20 and 29 were analyzed. To identify the newly developed AP, the linked claims database was used.
Results: The incidence rates of AP were 18.8 and 9.8 per 100,000 person-years in male and female participants, respectively. Alcohol consumption and smoking were associated with the heightened risk of AP. The risk of AP development was increased as daily alcohol consumption increased. In addition, ex-smokers and current smokers showed higher AP risk than never smokers. Hypertriglyceridemia and obesity were associated with the increased AP risk as well. Compared with female participants, male participants showed a higher risk of AP in univariate analysis but showed a lower risk of AP in multivariate analysis.
Conclusions: In the young adult population, alcohol consumption, smoking, hypertriglyceridemia, and obesity were associated with an elevated risk of developing AP. It is important to identify and manage the modifiable AP risk factors in young adults to minimize the socioeconomic burden of AP.
研究目的本研究旨在根据韩国全国范围内的队列数据,确定20多岁年轻人患急性胰腺炎(AP)的风险因素:方法:从 2009 年韩国全国健康检查数据库中分析了 471,098 名年龄在 20 岁至 29 岁之间的人。方法:从 2009 年韩国全国健康检查数据库中分析了 471,098 名 20 至 29 岁的人,并使用关联的索赔数据库来识别新发的 AP:结果:男性和女性的 AP 发病率分别为每 10 万人年 18.8 例和 9.8 例。饮酒和吸烟与罹患 AP 的风险增加有关。随着每日饮酒量的增加,患 AP 的风险也随之增加。此外,与从不吸烟者相比,曾经吸烟者和目前吸烟者患 AP 的风险更高。高甘油三酯血症和肥胖也与 AP 风险增加有关。与女性参试者相比,男性参试者在单变量分析中患 AP 的风险较高,但在多变量分析中患 AP 的风险较低:结论:在年轻人群中,饮酒、吸烟、高甘油三酯血症和肥胖与罹患 AP 的风险升高有关。重要的是,要识别和管理青壮年中可改变的 AP 风险因素,以尽量减轻 AP 带来的社会经济负担。
期刊介绍:
Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.