Decreased Serum Cocaine- and Amphetamine-Regulated Transcript Level in Internet Gaming Disorder

IF 17.7 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2024-07-25 DOI:10.30773/pi.2023.0397

Ara Cho, Heejin Lee, D. Cheon, So Young Yoo, Arom Pyeon, J. Chun, Ji Hyun Back, Yae Eun Park, Dai-Jin Kim, Ji Eun Lee, Jung-Seok Choi

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Abstract

Objective Vulnerability to internet gaming disorder (IGD) has increased as internet gaming continues to grow. Cocaine- and amphetamine-regulated transcript (CART) is a hormone that plays a role in reward, anxiety, and stress. The purpose of this study was to identify the role of CART in the pathophysiology of IGD.Methods The serum CART levels were measured by enzyme-linked immunosorbent assay, and the associations of the serum CART level with psychological variables were analyzed in patients with IGD (n=31) and healthy controls (HC) (n=42).Results The serum CART level was significantly lower in the IGD than HC group. The IGD group scored significantly higher than the HC group on the psychological domains of depression, anxiety, the reward response in the Behavioral Activation System and Behavioral Inhibition System. There were no significant correlations between serum CART level and other psychological variables in the IGD group.Conclusion Our results indicate that a decrease in the expression of the serum CART level is associated with the vulnerability of developing IGD. This study supports the possibility that CART is a biomarker in the pathophysiology of IGD.

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网络游戏障碍患者血清中可卡因和苯丙胺调节转录物水平降低

随着网络游戏的不断发展，易患网络游戏障碍（IGD）的人群也在不断增加。可卡因和苯丙胺调节转录物（CART）是一种激素，在奖赏、焦虑和压力中发挥作用。方法采用酶联免疫吸附法测定血清CART水平，分析IGD患者（31人）和健康对照组（42人）血清CART水平与心理变量的关系。IGD 组在抑郁、焦虑、行为激活系统奖赏反应和行为抑制系统等心理领域的得分明显高于 HC 组。结论我们的研究结果表明，血清 CART 水平的下降与易患 IGD 有关。本研究证实了 CART 是 IGD 病理生理学中的一种生物标志物的可能性。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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