Decreased Serum Cocaine- and Amphetamine-Regulated Transcript Level in Internet Gaming Disorder

IF 1.8 4区医学 Q3 PSYCHIATRY Psychiatry Investigation Pub Date : 2024-07-25 DOI:10.30773/pi.2023.0397

Ara Cho, Heejin Lee, D. Cheon, So Young Yoo, Arom Pyeon, J. Chun, Ji Hyun Back, Yae Eun Park, Dai-Jin Kim, Ji Eun Lee, Jung-Seok Choi

{"title":"Decreased Serum Cocaine- and Amphetamine-Regulated Transcript Level in Internet Gaming Disorder","authors":"Ara Cho, Heejin Lee, D. Cheon, So Young Yoo, Arom Pyeon, J. Chun, Ji Hyun Back, Yae Eun Park, Dai-Jin Kim, Ji Eun Lee, Jung-Seok Choi","doi":"10.30773/pi.2023.0397","DOIUrl":null,"url":null,"abstract":"Objective Vulnerability to internet gaming disorder (IGD) has increased as internet gaming continues to grow. Cocaine- and amphetamine-regulated transcript (CART) is a hormone that plays a role in reward, anxiety, and stress. The purpose of this study was to identify the role of CART in the pathophysiology of IGD.Methods The serum CART levels were measured by enzyme-linked immunosorbent assay, and the associations of the serum CART level with psychological variables were analyzed in patients with IGD (n=31) and healthy controls (HC) (n=42).Results The serum CART level was significantly lower in the IGD than HC group. The IGD group scored significantly higher than the HC group on the psychological domains of depression, anxiety, the reward response in the Behavioral Activation System and Behavioral Inhibition System. There were no significant correlations between serum CART level and other psychological variables in the IGD group.Conclusion Our results indicate that a decrease in the expression of the serum CART level is associated with the vulnerability of developing IGD. This study supports the possibility that CART is a biomarker in the pathophysiology of IGD.","PeriodicalId":21164,"journal":{"name":"Psychiatry Investigation","volume":null,"pages":null},"PeriodicalIF":1.8000,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Psychiatry Investigation","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.30773/pi.2023.0397","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PSYCHIATRY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective Vulnerability to internet gaming disorder (IGD) has increased as internet gaming continues to grow. Cocaine- and amphetamine-regulated transcript (CART) is a hormone that plays a role in reward, anxiety, and stress. The purpose of this study was to identify the role of CART in the pathophysiology of IGD.Methods The serum CART levels were measured by enzyme-linked immunosorbent assay, and the associations of the serum CART level with psychological variables were analyzed in patients with IGD (n=31) and healthy controls (HC) (n=42).Results The serum CART level was significantly lower in the IGD than HC group. The IGD group scored significantly higher than the HC group on the psychological domains of depression, anxiety, the reward response in the Behavioral Activation System and Behavioral Inhibition System. There were no significant correlations between serum CART level and other psychological variables in the IGD group.Conclusion Our results indicate that a decrease in the expression of the serum CART level is associated with the vulnerability of developing IGD. This study supports the possibility that CART is a biomarker in the pathophysiology of IGD.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

网络游戏障碍患者血清中可卡因和苯丙胺调节转录物水平降低

随着网络游戏的不断发展，易患网络游戏障碍（IGD）的人群也在不断增加。可卡因和苯丙胺调节转录物（CART）是一种激素，在奖赏、焦虑和压力中发挥作用。方法采用酶联免疫吸附法测定血清CART水平，分析IGD患者（31人）和健康对照组（42人）血清CART水平与心理变量的关系。IGD 组在抑郁、焦虑、行为激活系统奖赏反应和行为抑制系统等心理领域的得分明显高于 HC 组。结论我们的研究结果表明，血清 CART 水平的下降与易患 IGD 有关。本研究证实了 CART 是 IGD 病理生理学中的一种生物标志物的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Psychiatry Investigation PSYCHIATRY-

CiteScore

4.10

自引率

3.70%

发文量

105

审稿时长

6-12 weeks

期刊介绍： The Psychiatry Investigation is published on the 25th day of every month in English by the Korean Neuropsychiatric Association (KNPA). The Journal covers the whole range of psychiatry and neuroscience. Both basic and clinical contributions are encouraged from all disciplines and research areas relevant to the pathophysiology and management of neuropsychiatric disorders and symptoms, as well as researches related to cross cultural psychiatry and ethnic issues in psychiatry. The Journal publishes editorials, review articles, original articles, brief reports, viewpoints and correspondences. All research articles are peer reviewed. Contributions are accepted for publication on the condition that their substance has not been published or submitted for publication elsewhere. Authors submitting papers to the Journal (serially or otherwise) with a common theme or using data derived from the same sample (or a subset thereof) must send details of all relevant previous publications and simultaneous submissions. The Journal is not responsible for statements made by contributors. Material in the Journal does not necessarily reflect the views of the Editor or of the KNPA. Manuscripts accepted for publication are copy-edited to improve readability and to ensure conformity with house style.