Use of Topical Minocycline for Treatment of Confluent and Reticulated Papillomatosis

Shannon Meledathu, Helen Nguyen, Zain Husain
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Abstract

Confluent and reticulated papillomatosis (CRP) is a rare dermatosis initially that typically affects young adults and is characterized by scaly, hyperpigmented macules or papillomatous papules combining into patches typically involving the upper trunk and neck. Herein, we report two cases of CRP successfully treated with topical minocycline. The most widely accepted treatment of CRP to date is oral minocycline. Due to the chronic nature of CRP, topical minocycline could be considered a better first-line treatment option. This alternative treatment offers the advantage of a targeted, local application for enhanced skin bioavailability and efficacy. This case supports the possibility of topical minocycline use as an alternative to long-term oral antibiotics for treatment of CRP.
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使用局部米诺环素治疗汇合型和网状乳头状瘤病
汇集性网状乳头状瘤病(CRP)是一种罕见的皮肤病,最初通常发生在青壮年身上,其特征是鳞屑状、色素沉着性斑丘疹或乳头状丘疹合并成斑块,通常累及躯干上部和颈部。在此,我们报告了两例使用局部米诺环素成功治疗 CRP 的病例。迄今为止,最广为接受的 CRP 治疗方法是口服米诺环素。由于 CRP 的慢性性质,局部米诺环素可被视为更好的一线治疗方案。这种替代疗法的优点是可以有针对性地局部使用,从而提高皮肤的生物利用度和疗效。本病例支持局部使用米诺环素替代长期口服抗生素治疗 CRP 的可能性。
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