Effect of Different MMP Inhibitors on the Bond Strength and Durability of an Etch-and-rinse and a Self-etch Adhesive

Ado klinik bilimler dergisi Pub Date : 2024-07-19 DOI:10.54617/adoklinikbilimler.1485108

A. Hazar, Mine Betül Üçtaşlı

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Abstract

Aim: To compare the effect of different matrix metalloproteinase (MMP) inhibitors on the microtensile bond strength (μTBS) of an etch-and-rinse adhesive and a self-etch adhesive at baseline and after aging. Materials and Method: Flat dentin surfaces were prepared from 96 extracted, sound human molars. Teeth were randomly divided into two main groups according to the adhesives (Adper Single Bond 2, and Clearfil 3S Plus) used (n=48). Each group was divided into four subgroups according to the dentin surface treatments; untreated (control), pretreated with 2% chlorhexidine digluconate (CHX) before adhesive application, pretreated with 1% benzalkonium chloride (BAC) before adhesive application, and pretreated with 2% hesperidin (HPN) before adhesive application (n=12). Composite resin was then placed on the prepared surfaces and polymerized. The specimens were cut to obtain dentin beams and randomly divided into two groups for microtensile analysis at baseline and after 6 months of aging. Failure types were observed test after microtensile tests and data were analyzed by Two-way ANOVA, Tukey HSD, and Chi-Square tests (p

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不同的 MMP 抑制剂对蚀洗型粘合剂和自酸蚀型粘合剂的粘合强度和耐久性的影响

目的：比较不同基质金属蛋白酶（MMP）抑制剂对蚀刻-冲洗粘合剂和自酸蚀粘合剂在基线和老化后的微拉伸粘接强度（μTBS）的影响。材料和方法：从 96 颗拔出的健全人类臼齿上制备平面牙本质表面。根据使用的粘合剂（Adper Single Bond 2 和 Clearfil 3S Plus）将牙齿随机分为两大组（n=48）。每组又根据牙本质表面处理分为四个亚组：未处理组（对照组）、使用粘合剂前用 2% 洗必泰二氯葡萄糖酸盐（CHX）预处理组、使用粘合剂前用 1% 苯扎氯铵（BAC）预处理组和使用粘合剂前用 2% 七叶皂苷（HPN）预处理组（n=12）。然后将复合树脂置于制备好的表面并进行聚合。将试样切割成牙本质梁，并随机分为两组，分别在基线和老化 6 个月后进行显微拉伸分析。微拉伸试验后观察失效类型，并通过双向方差分析、Tukey HSD 和 Chi-Square 检验对数据进行分析（p＜0.05）。

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