Healing of tooth extraction wound socket, do we have current understanding?

IF 0.4 Q4 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Oral and Maxillofacial Surgery Medicine and Pathology Pub Date : 2024-07-20 DOI:10.1016/j.ajoms.2024.07.009

Aqsa Kamal , Maryam Kamal , Alina Hasnat , Abeera Mohsin , A.R. Samsudin

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Abstract

Objective

This review paper aims to provide an up to date understanding on tooth socket healing signifying the impact of osteoimmunology, cellular and molecular events, role of nerves, growth factors, signaling pathways, oxygen, endocrine and obesity in healing and regeneration.

Methods

A thorough literature search was conducted using up to date software and electronic databases including Python 3.9.7 and latent Dirichlet allocation (LDA).

Results

70 relevant articles were included. Tooth socket healing is different from other types of bone healing.

Conclusion

Role of osteoimmunology, macrophages, mesenchymal stem cells, growth factors, hormones and nerves in tooth socket healing have been ignored for long. These factors can result in impaired wound healing or disruption the healing process. Understanding the mechanisms involved in tooth socket healing can contribute to the development of targeted strategies for promoting optimal healing outcomes.

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拔牙创口的愈合，我们目前了解多少？

方法使用最新的软件和电子数据库，包括Python 3.9.7和潜狄利克特分配（LDA），对文献进行了全面检索。结果共收录了70篇相关文章。结论长期以来，骨免疫学、巨噬细胞、间充质干细胞、生长因子、激素和神经在牙槽骨愈合中的作用一直被忽视。这些因素会导致伤口愈合受损或愈合过程中断。了解牙槽骨愈合的相关机制有助于制定有针对性的策略，促进最佳愈合效果。

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