Combined Phacoemulsification and Hydrus Microstent Implantation in Asian Eyes With Moderate-to-Severe Normal Tension Glaucoma-12-Month Outcomes.

IF 2 4区 医学 Q2 OPHTHALMOLOGY Journal of Glaucoma Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI:10.1097/IJG.0000000000002475
Bryan Chin Hou Ang, Elizabeth Jiahui Chen, Wai Kitt Chee, Bjorn Kaijun Betzler, Chun Hau Chua, Vivien Cherng Hui Yip, Leonard Wei Leon Yip
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Abstract

Prcis: This study reports 12-month outcomes of combined phacoemulsification and Hydrus Microstent implantation in Asian eyes with moderate-to-severe normal tension glaucoma (NTG), demonstrating a significant reduction in glaucoma medications with an excellent intra and postoperative safety profile.

Objective: To evaluate the 12-month safety and efficacy outcomes of combined phacoemulsification and Hydrus Microstent (Ivantis Inc.) implantation in Asian eyes with moderate to severe NTG.

Methods: Retrospective study of consecutive surgeries performed from August 2019 to August 2021 in a single tertiary eye centre in Singapore. Outcome measures included a reduction in intraocular pressure (IOP), number of glaucoma medications, and intra and postoperative complications.

Results: Data from 21 eyes of 21 subjects were analyzed. All subjects were ethnic Chinese, and the majority were males (14, 66.7%). At baseline, the mean IOP was 13.3 (2.3) mm Hg, all eyes had a Humphrey visual field mean deviation of ≥-6 dB [mean: -13.9 (4.3) dB], and all eyes were on at least one glaucoma medication. There was no statistically significant reduction in IOP at all time points compared with baseline (all P > 0.05). However, the median number of medications was reduced from 2 to 0 at all time points, up to postoperative month (POM) 12 (all P < 0.001). There were no intraoperative complications. No eyes underwent secondary glaucoma procedures nor lost any Snellen line of visual acuity by POM12. One (4.8%) eye experienced numerical hypotony at postoperative day 1, which resolved conservatively. Two (9.5%) eyes underwent laser iridoplasty for stent occlusion by iris. There was no deterioration in Humphrey visual field mean deviation at POM12 compared with baseline (n = 20, P > 0.05).

Conclusion: Combined phacoemulsification and Hydrus Microstent implantation were effective in reducing medication burden in Asian eyes with moderate to severe NTG, up to 12 months postoperatively.

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中重度正常张力青光眼亚裔患者的联合超声乳化和 Hydrus 微支架植入术 - 12 个月疗效。
摘要目的:评估中重度正常张力青光眼(NTG)亚裔患者接受联合超声乳化和Hydrus微支架(Ivantis Inc.,Irvine,CA)植入手术的12个月安全性和疗效:方法:对新加坡一家三级眼科中心在2019年8月至2021年8月期间进行的连续手术进行回顾性研究。结果:21 名受试者的 21 只眼睛的数据被纳入研究:结果:分析了 21 名受试者 21 只眼睛的数据。所有受试者均为中国人,男性占大多数(14 人,66.7%)。基线时,平均眼压为 13.3 (2.3) mmHg,所有眼睛的汉弗莱视野(HVF)平均偏差(MD)≥-6 dB [平均 -13.9 (4.3) dB],所有眼睛至少服用一种青光眼药物。与基线相比,所有时间点的眼压均无统计学意义上的明显降低(P>0.05)。然而,在所有时间点,药物中位数从 2 种降至 0 种,直至 POM12(均为 P0.05):结论:对于患有中度至重度NTG的亚裔患者,联合乳化手术和Hydrus微支架植入术能有效减轻其术后12个月的用药负担。
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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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