The diagnostic value of prostate-specific membrane antigen PET-CT in differentiating medication-related osteonecrosis of the jaw and metastasis to the jawbone.

IF 2.9 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Dento maxillo facial radiology Pub Date : 2024-10-01 DOI:10.1093/dmfr/twae034
Karin Kur, Erofili Papadopoulou, Meital Nidam, Michal Fertouk, Omer Binyamini, Silvina Friedlander Barenboim, Towy Sorel Lazarovitci, Liran Domachevsky, Noam Yarom
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Abstract

Introduction: Medication-related osteonecrosis of the jaw (MRONJ) and jaw metastasis might share similar clinical and radiographic characteristics, with both demonstrating F-18 fluorodeoxyglucose (FDG) uptake on PET-CT. Prostate-specific membrane antigen (PSMA) PET-CT is used to demonstrate prostate cancer dissemination. Unlike FDG PET-CT, PSMA PET-CT is more specific to cancer than to inflammation. Therefore, we hypothesized that it might be a useful tool to differentiate between MRONJ and jaw metastasis.

Methods: All files of prostate cancer patients diagnosed with MRONJ and with available PSMA PET-CT studies were retrieved. A similar number of solid cancer patients with MRONJ and with available FDG PET-CT studies served as a second study group. All studies were reviewed by 2 blinded co-investigators (L.D. and M.F.).

Results: Seventeen patients who underwent PSMA PET-CT (24 studies) and 15 patients who underwent FDG PET-CT (29 studies) met the inclusion criteria. All patients with FDG PET-CT studies showed pathological uptake at the site of MRONJ in at least one of their studies versus only 23.5% of patients in the PSMA PET-CT group (P < .001). FDG PET-CT studies showed pathological uptake in 89.6% of the studies compared with only 20.8% in the PSMA PET-CT group (P < .001). The mean standardized uptake value (SUVmax) and the mean uptake volume in the FDG PET-CT group were significantly higher compared with the PSMA PET-CT group (P < .001 and P < .005, respectively). The interclass correlation coefficient for all parameters was higher than 0.95.

Conclusions: PSMA PET-CT is useful to differentiate between MRONJ and jaw metastasis.

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PSMA PET-CT 在鉴别药物性颌骨骨坏死和颌骨转移方面的诊断价值。
导言:药物相关性颌骨坏死(MRONJ)和颌骨转移可能具有相似的临床和影像学特征,两者在 PET-CT 上均显示 FDG 摄取。前列腺特异性膜抗原(PSMA)PET-CT用于显示前列腺癌的扩散。与 FDG PET-CT 不同,PSMA PET-CT 对癌症的特异性高于对炎症的特异性。因此,我们假设它可能是区分 MRONJ 和颌骨转移的有用工具:我们检索了所有确诊为 MRONJ 并进行过 PSMA PET-CT 研究的前列腺癌患者的档案。同样数量的患有 MRONJ 并可进行 FDG PET-CT 研究的实体癌患者作为第二组研究对象。所有研究均由两名盲法共同研究者(LD、MF)进行审查:17名接受 PSMA PET-CT 检查的患者(24 项研究)和 15 名接受 FDG PET-CT 检查的患者(29 项研究)符合纳入标准。所有接受 FDG PET-CT 研究的患者至少有一项研究显示 MRONJ 位点存在病理摄取,而 PSMA PET-CT 组仅有 23.5% 的患者显示 MRONJ 位点存在病理摄取(P 结论:PSMA PET-CT 对肺癌的诊断非常有用:PSMA PET-CT 可用于区分 MRONJ 和颌骨转移。
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来源期刊
CiteScore
5.60
自引率
9.10%
发文量
65
审稿时长
4-8 weeks
期刊介绍: Dentomaxillofacial Radiology (DMFR) is the journal of the International Association of Dentomaxillofacial Radiology (IADMFR) and covers the closely related fields of oral radiology and head and neck imaging. Established in 1972, DMFR is a key resource keeping dentists, radiologists and clinicians and scientists with an interest in Head and Neck imaging abreast of important research and developments in oral and maxillofacial radiology. The DMFR editorial board features a panel of international experts including Editor-in-Chief Professor Ralf Schulze. Our editorial board provide their expertise and guidance in shaping the content and direction of the journal. Quick Facts: - 2015 Impact Factor - 1.919 - Receipt to first decision - average of 3 weeks - Acceptance to online publication - average of 3 weeks - Open access option - ISSN: 0250-832X - eISSN: 1476-542X
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