The role of radiotherapy in the treatment of sinonasal undifferentiated carcinoma: A population-based analysis.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-07-31 DOI:10.1002/hed.27862

Xin Zhao, Ziqi Pei, Xiang Song, Gang Jin

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Abstract

Background: Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.

Methods: Retrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.

Results: The 5-year cancer-specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84-month median follow-up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299-0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303-0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5-year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.

Conclusions: Radiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.

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放射治疗在鼻窦未分化癌治疗中的作用：基于人群的分析。

背景：鼻窦未分化癌（SNUC）是一种罕见的侵袭性疾病，治疗不明确，预后差。本研究旨在评估放射治疗（RT）的作用，并探索最佳治疗顺序：方法：对1973年至2015年间410例SNUC患者的生存趋势进行回顾性分析：结果：在84个月的中位随访中，5年癌症特异性生存率（CSS）为45.1%，总生存率（OS）为38.1%。放疗是改善 CSS 的预后指标（危险比 [HR] = 0.425，95% 置信区间 [CI]：0.299-0.603）：0.299-0.603, p = 0.000）和OS（HR = 0.415, 95% CI: 0.303-0.570, p = 0.000）。然而，在手术和 RT 的联合治疗中，术前和术后 RT（5 年 OS 率分别为 47.1% 和 45.6%，p = 0.486）没有显著差异：结论：放疗在提高SNUC生存率方面发挥着关键作用。结论：放疗在提高SNUC生存率方面发挥着关键作用，术前和术后RT治疗在生存率方面无明显差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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