Yi Ma, Hao-Jie Guo, Jing-An Li, Yan-Chao Wang, Yi-Fan Zhou
{"title":"A biologically multifunctional PDA-LYS composite coating is fabricated on the surface of magnesium alloy vascular stents to promote endothelialization","authors":"Yi Ma, Hao-Jie Guo, Jing-An Li, Yan-Chao Wang, Yi-Fan Zhou","doi":"10.1557/s43578-024-01386-6","DOIUrl":null,"url":null,"abstract":"<p>Due to their excellent mechanical properties and biodegradability, biodegradable magnesium alloy vascular stents have become a hot topic in current research on vascular stent material. However, the further application of magnesium alloy is limited by its rapid degradation rate and insufficient ability to promote surface endothelialization. This study proposed a strategy of co-depositing a PDA-LYS coating on the surface of magnesium alloy treated with an alkaline pre-heating process. Experimental results demonstrated that the PDA-LYS composite coating significantly improved the corrosion resistance of the magnesium alloy. Furthermore, with the increase in LYS content in the samples, the coating facilitated the adhesion and proliferation of endothelial cells and effectively inhibited the excessive proliferation of pathological smooth muscle cells. In summary, the PDA-LYS composite coating had a positive impact on the biocompatibility of magnesium alloy, which has offered a new approach for surface modification of magnesium alloy vascular materials.</p><h3 data-test=\"abstract-sub-heading\">Graphical abstract</h3>\n","PeriodicalId":16306,"journal":{"name":"Journal of Materials Research","volume":"213 1","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Materials Research","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1557/s43578-024-01386-6","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Due to their excellent mechanical properties and biodegradability, biodegradable magnesium alloy vascular stents have become a hot topic in current research on vascular stent material. However, the further application of magnesium alloy is limited by its rapid degradation rate and insufficient ability to promote surface endothelialization. This study proposed a strategy of co-depositing a PDA-LYS coating on the surface of magnesium alloy treated with an alkaline pre-heating process. Experimental results demonstrated that the PDA-LYS composite coating significantly improved the corrosion resistance of the magnesium alloy. Furthermore, with the increase in LYS content in the samples, the coating facilitated the adhesion and proliferation of endothelial cells and effectively inhibited the excessive proliferation of pathological smooth muscle cells. In summary, the PDA-LYS composite coating had a positive impact on the biocompatibility of magnesium alloy, which has offered a new approach for surface modification of magnesium alloy vascular materials.
期刊介绍:
Journal of Materials Research (JMR) publishes the latest advances about the creation of new materials and materials with novel functionalities, fundamental understanding of processes that control the response of materials, and development of materials with significant performance improvements relative to state of the art materials. JMR welcomes papers that highlight novel processing techniques, the application and development of new analytical tools, and interpretation of fundamental materials science to achieve enhanced materials properties and uses. Materials research papers in the following topical areas are welcome.
• Novel materials discovery
• Electronic, photonic and magnetic materials
• Energy Conversion and storage materials
• New thermal and structural materials
• Soft materials
• Biomaterials and related topics
• Nanoscale science and technology
• Advances in materials characterization methods and techniques
• Computational materials science, modeling and theory