{"title":"One-pot multicomponent approach towards the synthesis of 5-substituted 1H-tetrazoles using lanthanum (III) nitrate hexahydrate as a catalyst","authors":"Kumaraswamy Gullapelli, Ramesh Nukala, Saidulu Ganji, Ramesh Kola, Ravichandar Maroju","doi":"10.1007/s11164-024-05365-8","DOIUrl":null,"url":null,"abstract":"<div><p>An intriguing trend in the synthesis of heterocyclic compounds is green chemistry, which involves using environmentally friendly reagents and efficient reactions to suit the demands of the pharmaceutical sector. This study is a part of continuous endeavour to advance novel synthetic approaches for the synthesis of heterocyclic molecules. With lanthanum nitrate hexahydrate as a catalyst, a procedure for the synthesis of tetrazoles was described in this work. The ideal 10% mole ratio of La(NO<sub>3</sub>)<sub>3</sub>·6H<sub>2</sub>O catalyst with DMF solvent produced good yields of the intended products, ranging from 85 to 98%, according to the results. High product yields, cost effectiveness, and operational simplicity are just a few benefits of using La(NO<sub>3</sub>)<sub>3</sub>·6H<sub>2</sub>O as a catalyst in this condensation reaction. The chemical structures of the synthesized tetrazoles were analyzed and characterized using <sup>1</sup>HNMR, <sup>13</sup>C-NMR, and mass spectra (HRMS).</p><h3>Graphical abstract</h3>\n<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":753,"journal":{"name":"Research on Chemical Intermediates","volume":"50 9","pages":"4407 - 4423"},"PeriodicalIF":2.8000,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research on Chemical Intermediates","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11164-024-05365-8","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
An intriguing trend in the synthesis of heterocyclic compounds is green chemistry, which involves using environmentally friendly reagents and efficient reactions to suit the demands of the pharmaceutical sector. This study is a part of continuous endeavour to advance novel synthetic approaches for the synthesis of heterocyclic molecules. With lanthanum nitrate hexahydrate as a catalyst, a procedure for the synthesis of tetrazoles was described in this work. The ideal 10% mole ratio of La(NO3)3·6H2O catalyst with DMF solvent produced good yields of the intended products, ranging from 85 to 98%, according to the results. High product yields, cost effectiveness, and operational simplicity are just a few benefits of using La(NO3)3·6H2O as a catalyst in this condensation reaction. The chemical structures of the synthesized tetrazoles were analyzed and characterized using 1HNMR, 13C-NMR, and mass spectra (HRMS).
期刊介绍：
Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry.
The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.
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