Screening of cytokine expression in human seminal plasma in associations with sperm disorders and markers of oxidative-antioxidant balance

IF 3.7 3区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Cytokine Pub Date : 2024-07-31 DOI:10.1016/j.cyto.2024.156701
Sylwia Płaczkowska , Izabela Kokot , Iwona Gilowska , Ewa Maria Kratz
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Abstract

Among the many factors with a proven relation to semen quality and male fertility, the determination of seminal plasma cytokines provides a promising direction for research into the identification of factors connected with male infertility. The interleukins: IL-1α, -1β, -2, -4, -6, -8, -10, -12p40, -12p70, -18, IFNγ, and GM-CSF, total oxidant (TOS) and antioxidant (TAS) status, were simultaneously examined in seminal plasmas and blood sera in terato- (n = 32), asthenoterato- (n = 33), and oligoasthenoteratozoospermic (n = 29) infertile men and in normozoospermic fertile men (n = 20). Our research shows different cytokine composition of the sera and seminal plasmas in all studied groups, along with much higher concentrations of seminal plasma GM-CSF, IFNγ, IL-1α, IL-4, IL-6, and IL-8 and lower IL-18 and TOS in the comparison to their sera levels. The seminal plasma concentrations of GM-CSF, IFNγ, IL-1α, -4, and -6 differ significantly between fertile and infertile as well as between teratozoospermic, asthenoteratozoospermic, and oligoasthenoteratozoospermic groups. The indication of the cause of different concentrations of cytokines in seminal plasmas of infertile men, and their associations with semen parameters and oxidative status, may be a promising direction for the search for new therapeutic targets that would directly affect the cells and tissues of male reproductive organs.

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筛查人类精浆中细胞因子的表达与精子疾病和氧化-抗氧化平衡标志物的关系。
在众多已被证实与精液质量和男性生育能力有关的因素中,精浆细胞因子的测定为确定与男性不育有关的因素提供了一个很有前景的研究方向。白细胞介素研究人员同时检测了畸形精子(32 人)精浆和血清中的白细胞介素:IL-1α、-1β、-2、-4、-6、-8、-10、-12p40、-12p70、-18、IFNγ 和 GM-CSF、总氧化剂(TOS)和抗氧化剂(TAS)状态、我们同时检测了畸形精子症男性(32 人)和少精子症男性(33 人)以及正常精子症男性(20 人)的精浆和血清中的细胞因子状态。我们的研究表明,在所有研究组中,血清和精浆中的细胞因子组成不同,精浆中 GM-CSF、IFNγ、IL-1α、IL-4、IL-6 和 IL-8 的浓度比血清中的浓度高得多,而 IL-18 和 TOS 的浓度则比血清中的浓度低。精浆中 GM-CSF、IFNγ、IL-1α、-4 和 -6 的浓度在可育和不育之间以及畸形精子症、无精子症和少精子症组之间存在显著差异。不育男性精浆中细胞因子浓度不同的原因及其与精液参数和氧化状态的关系,可能是寻找直接影响男性生殖器官细胞和组织的新治疗靶点的一个有希望的方向。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cytokine
Cytokine 医学-免疫学
CiteScore
7.60
自引率
2.60%
发文量
262
审稿时长
48 days
期刊介绍: The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.
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