Cyclotron production of manganese-52: a promising avenue for multimodal PET/MRI imaging

IF 4.4 Q1 CHEMISTRY, INORGANIC & NUCLEAR EJNMMI Radiopharmacy and Chemistry Pub Date : 2024-08-02 DOI:10.1186/s41181-024-00288-6

Francesca Porto, Sara Cisternino, Emiliano Cazzola, Giorgia Speltri, Liliana Mou, Alessandra Boschi, Lorenza Marvelli, Giovanni Di Domenico, Antonella Pagnoni, Lucia De Dominicis, Irene Calliari, Claudio Gennari, Licia Uccelli, Gaia Pupillo, Giancarlo Gorgoni, Juan Esposito, Petra Martini

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Abstract

Background

The integration of positron emission tomography (PET) and magnetic resonance imaging (MRI) holds promise for advancing diagnostic imaging capabilities. The METRICS project aims to develop cyclotron-driven production of ⁵²Mn for PET/MRI imaging.

Results

Using the ⁵²Cr(p,n)⁵²Mn reaction, we designed chromium metal targets via Spark Plasma Sintering and developed a separation procedure for isolating ⁵²Mn. Labeling tests were conducted with traditional chelators (i.e. S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid) and the 1.4-dioxa-8-azaspiro[4.5]decane-8- carbodithioate ligand to produce radioactive complexes suitable for PET/MRI applications. Our methodology yielded high-quality ⁵²Mn suitable for PET radiopharmaceuticals and PET/MRI imaging. Preliminary studies on phantom imaging using microPET and clinical MRI demonstrated the efficacy of our approach.

Conclusions

The developed technology offers a promising avenue for producing ⁵²Mn and enhancing PET/MRI imaging capabilities. Further in vivo investigations are warranted to evaluate the potential advantages of this hybrid imaging technique.

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回旋加速器生产锰-52：多模态 PET/MRI 成像的前景广阔的途径。

背景：正电子发射断层扫描（PET）和磁共振成像（MRI）的整合有望提高成像诊断能力。METRICS 项目旨在开发用于 PET/MRI 成像的 52Mn 的回旋加速器驱动生产：利用 52Cr(p,n)52Mn反应，我们通过火花等离子烧结技术设计了铬金属靶，并开发了分离 52Mn 的分离程序。我们使用传统螯合剂（即 S-2-（4-异硫氰基苄基）-1,4,7,10-四氮杂环十二烷四乙酸）和 1.4-二氧杂-8-氮杂螺[4.5]癸烷-8-二硫代碳酸酯配体进行了标记测试，以生成适合 PET/MRI 应用的放射性配合物。我们的方法获得了适合 PET 放射性药物和 PET/MRI 成像的高质量 52Mn。使用 microPET 和临床 MRI 进行的模型成像初步研究证明了我们方法的有效性：结论：所开发的技术为生产 52Mn 和增强 PET/MRI 成像能力提供了一条前景广阔的途径。有必要进行进一步的体内研究，以评估这种混合成像技术的潜在优势。

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