Prospects for Disease Slowing in Parkinson Disease.

IF 11.2 1区 医学 Q1 PHARMACOLOGY & PHARMACY Annual review of pharmacology and toxicology Pub Date : 2024-08-01 DOI:10.1146/annurev-pharmtox-022124-033653
Elisa Menozzi, Anthony H V Schapira
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Abstract

The increasing prevalence of Parkinson disease (PD) highlights the need to develop interventions aimed at slowing or halting its progression. As a result of sophisticated disease modeling in preclinical studies, and refinement of specific clinical/genetic/pathological profiles, our understanding of PD pathogenesis has grown over the years, leading to the identification of several targets for disease modification. This has translated to the development of targeted therapies, many of which have entered clinical trials. Nonetheless, up until now, none of these treatments have satisfactorily shown disease-modifying effects in PD. In this review, we present the most up-to-date disease-modifying pharmacological interventions in the clinical trial pipeline for PD. We focus on agents that have reached more advanced stages of clinical trials testing, highlighting both positive and negative results, and critically reflect on strengths, weaknesses, and challenges of current disease-modifying therapeutic avenues in PD.

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帕金森病的疾病减缓前景。
帕金森病(Parkinson disease,PD)的发病率越来越高,这凸显了开发旨在减缓或阻止其发展的干预措施的必要性。由于在临床前研究中进行了复杂的疾病建模,并对特定的临床/遗传/病理特征进行了改进,多年来我们对帕金森病发病机制的了解不断加深,从而确定了多个疾病调节靶点。这促进了靶向疗法的开发,其中许多疗法已进入临床试验阶段。然而,到目前为止,这些疗法都没有令人满意地显示出对帕金森病的疾病改变作用。在这篇综述中,我们介绍了目前正在进行临床试验的最新的帕金森病疾病调整药物干预措施。我们将重点关注已进入临床试验测试更高级阶段的药物,同时强调积极和消极的结果,并批判性地反思目前帕金森病疾病调节治疗途径的优势、劣势和挑战。
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来源期刊
CiteScore
27.80
自引率
0.00%
发文量
53
期刊介绍: Since 1961, the Annual Review of Pharmacology and Toxicology has been a comprehensive resource covering significant developments in pharmacology and toxicology. The journal encompasses various aspects, including receptors, transporters, enzymes, chemical agents, drug development science, and systems like the immune, nervous, gastrointestinal, cardiovascular, endocrine, and pulmonary systems. Special topics are also featured in this annual review.
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