Interobserver Agreement Rates on CXCR4-Directed PET/CT in Patients with Marginal Zone Lymphoma.

IF 3 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Molecular Imaging and Biology Pub Date : 2024-10-01 Epub Date: 2024-08-01 DOI:10.1007/s11307-024-01940-y

Rudolf A Werner, Yingjun Zhi, Niklas Dreher, Samuel Samnick, Aleksander Kosmala, Takahiro Higuchi, Lena Bundschuh, Constantin Lapa, Andreas K Buck, Max S Topp, Hermann Einsele, Johannes Duell, Sebastian E Serfling, Ralph A Bundschuh

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Abstract

C-X-C motif chemokine receptor 4 (CXCR4)-directed molecular imaging provides excellent read-out capabilities in patients with marginal zone lymphoma (MZL). We aimed to determine the interobserver agreement rate of CXCR4-targeted PET/CT among readers with different levels of experience.

Methods: 50 subjects with MZL underwent CXCR4-targeted PET/CT, which were reviewed by four readers (including two experienced and two less experienced observers). The following 8 parameters were investigated: overall scan result, CXCR4 density in lymphoma tissue, extranodal organ involvement, No. of affected extranodal organs and extranodal organ metastases, lymph node (LN) involvement and No. of affected LN areas and LN metastases. We applied intraclass correlation coefficients (ICC; < 0.4, poor; 0.4-0.59, fair; 0.6-0.74, good and > 0.74 excellent agreement rates).

Results: Among all readers, fair agreement was recorded for No. of affected extranodal organs (ICC, 0.40; 95% confidence interval [CI], 0.25-0.68), overall scan result (ICC, 0.42; 95%CI, 0.28-0.57), CXCR4 density in lymphoma tissue (ICC, 0.52; 95%CI, 0.38-0.66), and No. of extranodal organ metastases (ICC, 0.55; 95%CI, 0.41-0.61) and LN involvement (ICC, 0.59; 95%CI, 0.46-0.71). Good agreement rates were observed for No. of LN metastases (ICC, 0.71; 95%CI, 0.60-0.81) and No. of LN areas (ICC, 0.73; 95%CI, 0.63-0.82), while extranodal organ involvement (ICC, 0.35; 95%CI, 0.21-0.51) achieved poor concordance. On a reader-by-reader comparison, the experienced readers achieved significantly higher agreement rates in 4/8 (50%) investigated scan items (ICC, range, 0.21-0.90, P < / = 0.04). In the remaining 4/8 (50%), a similar trend with higher ICCs for the experienced readers was recorded (n.s.).

Conclusion: CXCR4-directed PET/CT mainly provided fair to good agreement rates for scan assessment, while a relevant level of experience seems to be required for an accurate imaging read-out.

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边缘区淋巴瘤患者的 CXCR4 定向 PET/CT 观察者间一致率

C-X-C motif趋化因子受体4（CXCR4）定向分子成像为边缘区淋巴瘤（MZL）患者提供了出色的读出能力。方法：50 名 MZL 患者接受了 CXCR4 靶向 PET/CT 检查，由 4 名读者（包括 2 名经验丰富的观察者和 2 名经验较少的观察者）进行审查。我们对以下 8 个参数进行了研究：总体扫描结果、淋巴瘤组织中的 CXCR4 密度、结节外器官受累情况、受累结节外器官数量和结节外器官转移情况、淋巴结（LN）受累情况、受累 LN 区域数量和 LN 转移情况。我们采用了类内相关系数（ICC；0.74 的极好一致率）：57）、淋巴瘤组织中的 CXCR4 密度（ICC，0.52；95%CI，0.38-0.66）、结节外器官转移数量（ICC，0.55；95%CI，0.41-0.61）和 LN 受累数量（ICC，0.59；95%CI，0.46-0.71）。LN转移数量（ICC，0.71；95%CI，0.60-0.81）和LN区域数量（ICC，0.73；95%CI，0.63-0.82）的一致性较好，而结节外器官受累（ICC，0.35；95%CI，0.21-0.51）的一致性较差。在逐个读者比较中，经验丰富的读者在4/8（50%）个调查扫描项目中的一致率明显更高（ICC，范围为0.21-0.90，P 结论：CXCR4引导的PET-CT检查的一致率较高，而经验丰富的读者在4/8（50%）个调查扫描项目中的一致率较低：CXCR4引导的PET/CT主要为扫描评估提供了一般到良好的一致率，而准确的成像读出似乎需要相关的经验水平。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.