Novel role of CD34+ stromal cells/telocytes in oral submucous fibrosis development and its malignant transformation

IF 1.8 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2024-10-01 DOI:10.1016/j.jormas.2024.101990

Poonguzhalnalli Kumar , Dineshkumar Thayalan , Divya Bose , Rajkumar Krishnan , Rameshkumar Annasamy , Indumathi N

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Abstract

Background

Telocytes are interstitial cells widely distributed in the extracellular matrix of numerous tissues distinguished by their long, thin, and moniliform projections. Telocytes have a role in the stimulation of angiogenesis and contribute to the development and progression of fibrosis.

Aim

The current study aimed to assess and compare the telocyte distribution in normal mucosa, oral submucous fibrosis (OSF), and OSCC associated with OSF (OSCCOSF).

Materials and Methods

Formalin-fixed and paraffin-embedded tissue blocks of 30 OSF cases, 15 OSCCOSF cases, and 15 normal oral mucosae were obtained. Immunohistochemical staining was done with antibodies to CD34 to assess the vasculature and telocytes. The mean vascular density (MVD) and mean telocyte density were compared between the groups using the Kruskal-Walli test.

Results

A statistically significant high MVD (3.4 ± 1.22) and mean telocyte density (3.8 ± 1.35) was observed in OSCCOSF cases while it was lowest in advanced OSF cases. MVD was higher in early OSF cases than in normal mucosa.

Conclusion

This study showed a decrease in CD34-positive telocytes in OSF, indicating that telocyte loss promotes the development of fibrosis.Increased angiogenesis coexisted with an increase in telocytes in OSCCOSF.

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CD34+ 基质细胞/髓鞘细胞在口腔黏膜下纤维化发展及其恶性转化中的新作用

背景：端粒细胞是广泛分布于许多组织细胞外基质中的间质细胞，其特征是具有细长的单形突起。目的：本研究旨在评估和比较正常黏膜、口腔黏膜下纤维化（OSF）和伴有OSF的OSCC（OSCC-OSF）中端细胞的分布情况：获取 30 例 OSF、15 例 OSCC-OSF 和 15 例正常口腔黏膜的福尔马林固定和石蜡包埋组织块。用 CD34 抗体进行免疫组化染色，以评估血管和端粒细胞。采用 Kruskal-Walli 检验比较了组间的平均血管密度（MVD）和平均端粒细胞密度：结果：OSCC-OSF病例的平均血管密度（3.4 ± 1.22）和平均端粒细胞密度（3.8 ± 1.35）明显高于晚期OSF病例，差异具有统计学意义。早期OSF病例的MVD高于正常粘膜：本研究显示，OSF中CD34阳性端粒细胞减少，表明端粒细胞的丢失促进了纤维化的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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