Forensic toxicological studies of acute glufosinate poisoning: A case series

IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Journal of forensic and legal medicine Pub Date : 2024-08-01 DOI:10.1016/j.jflm.2024.102732
Shuang Zhao , Li Xiao , Yimin Sun , Zihan Jiang , Lin Yang , Jing Zhang , Yi Ye
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Abstract

Glufosinate is a widely and increasingly used non-selective, broad-spectrum herbicide. Although cases of glufosinate poisoning are frequently reported, they are rarely documented in forensic case reports, particularly in fatal instances. The present study examined six cases of glufosinate poisoning, including a fatal case involving a 25-year-old female found deceased by the roadside, with an empty 1000 mL bottle labeled "glufosinate" by her side. Biological specimens such as plasma or cardiac blood, gastric contents, and liver tissues were collected for quantitative analysis of glufosinate levels using LC-MS/MS. In five cases of acute glufosinate poisoning, glufosinate plasma concentrations ranged from 0.62 to 3.92 μg/mL. In the fatal case, the concentrations of glufosinate in cardiac blood, gastric contents, and liver tissues were 8.41 μg/mL, 31.25 μg/mL, and 66.1 μg/g, respectively. The pathological autopsy concluded that the cause of death was acute cardio-respiratory failure due to glufosinate poisoning, characterized by multi-organ congestion without specific pathological findings. The toxicological data provided in this study aim to serve as a critical reference for future clinical treatment and forensic validation of glufosinate poisoning-related deaths.

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急性草铵膦中毒的法医毒理学研究:系列病例。
草铵膦是一种广泛使用且使用范围越来越广的非选择性广谱除草剂。尽管草铵膦中毒事件经常见诸报道,但在法医案例报告中却鲜有记载,尤其是致命案例。本研究调查了六起草铵膦中毒事件,其中包括一起致命案件,涉及一名 25 岁的女性,她被发现死于路边,身边放着一个标有 "草铵膦 "字样的 1000 毫升空瓶。我们采集了血浆或心血、胃内容物和肝组织等生物标本,利用 LC-MS/MS 对草铵膦含量进行定量分析。在五例急性草铵膦中毒中,草铵膦的血浆浓度介于 0.62 至 3.92 μg/mL 之间。在死亡病例中,心血、胃内容物和肝组织中的草铵膦浓度分别为 8.41 μg/mL、31.25 μg/mL和 66.1 μg/g。病理解剖的结论是,死亡原因是草铵膦中毒导致的急性心肺功能衰竭,其特征是多器官充血,但没有具体的病理发现。本研究提供的毒理学数据旨在为今后草铵膦中毒相关死亡的临床治疗和法医鉴定提供重要参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
2.70
自引率
6.70%
发文量
106
审稿时长
57 days
期刊介绍: The Journal of Forensic and Legal Medicine publishes topical articles on aspects of forensic and legal medicine. Specifically the Journal supports research that explores the medical principles of care and forensic assessment of individuals, whether adult or child, in contact with the judicial system. It is a fully peer-review hybrid journal with a broad international perspective. The Journal accepts submissions of original research, review articles, and pertinent case studies, editorials, and commentaries in relevant areas of Forensic and Legal Medicine, Context of Practice, and Education and Training. The Journal adheres to strict publication ethical guidelines, and actively supports a culture of inclusive and representative publication.
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