Transdermal Asenapine for Agitation and Irritability in a Child With Complete Intravenous Dependence

IF 9.5 1区医学 Q1 PEDIATRICS Journal of the American Academy of Child and Adolescent Psychiatry Pub Date : 2025-02-01 DOI:10.1016/j.jaac.2024.07.913

Julia N. Stimpfl MD , Katherine C. Soe MD

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经皮阿塞那平治疗一名完全静脉依赖儿童的躁动和易激惹。

非典型抗精神病药物通常能有效控制神经发育障碍儿童的行为障碍；然而，对于那些依赖静脉注射和透皮途径的儿童来说，循证药物疗法却十分有限。美国食品和药物管理局（FDA）批准透皮阿塞那平用于治疗成人精神分裂症，但缺乏有关儿童使用和耐受性的数据。1,2阿塞那平舌下含服已获 FDA 批准用于小儿双相躁狂症的单药治疗（10-17 岁），但对青少年精神分裂症缺乏疗效。据报道，其儿科耐受性与其他第二代抗精神病药物相似，药代动力学和安全性数据与成人相当。3,6,7 我们介绍了一例 5 岁儿童的病例，经皮阿塞那平可有效、安全地控制躁动，改善对药物治疗的耐受性和生活质量。我们的病例表明，这可能是一种有效、耐受性良好的药物治疗方法，适用于部分儿童的躁动控制。本文发表前已获得监护人的知情同意。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Academy of Child and Adolescent Psychiatry 医学-精神病学

CiteScore

21.00

自引率

1.50%

发文量

1383

审稿时长

53 days

期刊介绍： The Journal of the American Academy of Child & Adolescent Psychiatry (JAACAP) is dedicated to advancing the field of child and adolescent psychiatry through the publication of original research and papers of theoretical, scientific, and clinical significance. Our primary focus is on the mental health of children, adolescents, and families. We welcome unpublished manuscripts that explore various perspectives, ranging from genetic, epidemiological, neurobiological, and psychopathological research, to cognitive, behavioral, psychodynamic, and other psychotherapeutic investigations. We also encourage submissions that delve into parent-child, interpersonal, and family research, as well as clinical and empirical studies conducted in inpatient, outpatient, consultation-liaison, and school-based settings. In addition to publishing research, we aim to promote the well-being of children and families by featuring scholarly papers on topics such as health policy, legislation, advocacy, culture, society, and service provision in relation to mental health. At JAACAP, we strive to foster collaboration and dialogue among researchers, clinicians, and policy-makers in order to enhance our understanding and approach to child and adolescent mental health.