{"title":"Synthesis of Indazole Scaffolds from Arynes and Suitable Coupling Partners - A Brief Review","authors":"Popuri Sureshbabu, Priyanka Chaudhary","doi":"10.2174/0118756298321262240719103850","DOIUrl":null,"url":null,"abstract":"Transition metal-free annulation/cascade reactions have been embraced as a powerful synthetic tool to access carbo/heterocyclic molecules. Among them, benzyne chemistry gained significant interest due to the formation of diverse functionalized arenes via unusual carboncarbon (C-C) or carbon-heteroatom (C-O, C-N, C-S) bond-formation under different reaction conditions. In this review, few dynamic methods have been documented to construct the synthetically and pharmaceutically valuable indazole scaffolds using benzyne precursor and various other coupling partners. In this mini-review, we have described the recent progress on metal-free cascade strategies, highlighting the contribution from several synthetic chemists, including our research work. Specific attention has been paid to offer the detailed mechanistic pathway to explain the developed methodologies.","PeriodicalId":18632,"journal":{"name":"Mini-reviews in Organic Chemistry","volume":"122 1","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Mini-reviews in Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.2174/0118756298321262240719103850","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Transition metal-free annulation/cascade reactions have been embraced as a powerful synthetic tool to access carbo/heterocyclic molecules. Among them, benzyne chemistry gained significant interest due to the formation of diverse functionalized arenes via unusual carboncarbon (C-C) or carbon-heteroatom (C-O, C-N, C-S) bond-formation under different reaction conditions. In this review, few dynamic methods have been documented to construct the synthetically and pharmaceutically valuable indazole scaffolds using benzyne precursor and various other coupling partners. In this mini-review, we have described the recent progress on metal-free cascade strategies, highlighting the contribution from several synthetic chemists, including our research work. Specific attention has been paid to offer the detailed mechanistic pathway to explain the developed methodologies.
期刊介绍:
Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges.
The journal encourages submission of reviews on emerging fields of organic chemistry including:
Bioorganic Chemistry
Carbohydrate Chemistry
Chemical Biology
Chemical Process Research
Computational Organic Chemistry
Development of Synthetic Methodologies
Functional Organic Materials
Heterocyclic Chemistry
Macromolecular Chemistry
Natural Products Isolation And Synthesis
New Synthetic Methodology
Organic Reactions
Organocatalysis
Organometallic Chemistry
Theoretical Organic Chemistry
Polymer Chemistry
Stereochemistry
Structural Investigations
Supramolecular Chemistry