Synthesis of Indazole Scaffolds from Arynes and Suitable Coupling Partners - A Brief Review

IF 1.9 4区 化学 Q2 CHEMISTRY, ORGANIC Mini-reviews in Organic Chemistry Pub Date : 2024-08-02 DOI:10.2174/0118756298321262240719103850
Popuri Sureshbabu, Priyanka Chaudhary
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Abstract

Transition metal-free annulation/cascade reactions have been embraced as a powerful synthetic tool to access carbo/heterocyclic molecules. Among them, benzyne chemistry gained significant interest due to the formation of diverse functionalized arenes via unusual carboncarbon (C-C) or carbon-heteroatom (C-O, C-N, C-S) bond-formation under different reaction conditions. In this review, few dynamic methods have been documented to construct the synthetically and pharmaceutically valuable indazole scaffolds using benzyne precursor and various other coupling partners. In this mini-review, we have described the recent progress on metal-free cascade strategies, highlighting the contribution from several synthetic chemists, including our research work. Specific attention has been paid to offer the detailed mechanistic pathway to explain the developed methodologies.
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从芳香烃和合适的偶联剂合成吲唑支架 - 简要回顾
无过渡金属环化/级联反应已被视为获得碳水化合物/杂环分子的强大合成工具。其中,苄烯化学因其在不同反应条件下通过不寻常的碳-碳(C-C)或碳-异原子(C-O、C-N、C-S)键形成的多种功能化烯而备受关注。在本综述中,使用苄烯前体和其他各种偶联剂构建具有合成和制药价值的吲唑支架的动态方法很少。在这篇微型综述中,我们介绍了无金属级联策略的最新进展,重点介绍了几位合成化学家的贡献,包括我们的研究工作。我们还特别注意提供详细的机理途径来解释所开发的方法。
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来源期刊
Mini-reviews in Organic Chemistry
Mini-reviews in Organic Chemistry 化学-有机化学
CiteScore
4.50
自引率
4.30%
发文量
116
审稿时长
>12 weeks
期刊介绍: Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry
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