Cyclic Mechanism Affects Lumbar Spine Creep Response.

IF 3 2区医学 Q3 ENGINEERING, BIOMEDICAL Annals of Biomedical Engineering Pub Date : 2024-08-04 DOI:10.1007/s10439-024-03595-w

Elizabeth D Dimbath, Concetta Morino, Shea Middleton, Jason Kait, Maria Ortiz-Paparoni, Theodore A Slotkin, Jason F Luck, Cameron R 'Dale' Bass

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Abstract

Purpose: This study aims to explore how cyclic loading influences creep response in the lumbar spine under combined flexion-compression loading.

Methods: Ten porcine functional spinal units (FSUs) were mechanically tested in cyclic or static combined flexion-compression loading. Creep response between loading regimes was compared using strain-time histories and linear regression. High-resolution computed tomography (µCT) visualized damage to FSUs. Statistical methods, ANCOVA and ANOVA, assessed differences in behavior between loading regimes.

Results: Cyclic and static loading regimes exhibited distinct creep response patterns and biphasic response. ANCOVA and ANOVA analyses revealed significant differences in slopes of creep behavior in both linear phases. Cyclic tests consistently showed endplate fractures in µCT imaging.

Conclusion: The study reveals statistically significant differences in creep response between cyclic and static loading regimes in porcine lumbar spinal units under combined flexion-compression loading. The observed biphasic behavior suggests distinct phases of tissue response, indicating potential shifts in load transfer mechanisms. Endplate fractures in cyclic tests suggest increased injury risk compared to static loading. These findings underscore the importance of considering loading conditions in computational models and designing preventive measures for occupations involving repetitive spinal loading.

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循环机制影响腰椎的蠕变反应

目的：本研究旨在探讨周期性加载如何影响腰椎在屈曲-压缩联合加载下的蠕变反应：方法：对十个猪功能脊柱单元（FSU）进行了循环或静态屈曲-压缩联合加载的机械测试。采用应变-时间历程和线性回归比较了不同加载模式下的蠕变响应。高分辨率计算机断层扫描（µCT）可视化 FSU 的损伤情况。采用方差分析和方差分析等统计方法评估了不同加载方式之间的行为差异：结果：循环加载和静态加载机制表现出不同的蠕变响应模式和双相响应。方差分析和方差分析显示，两种线性阶段的蠕变行为斜率存在显著差异。循环测试在 µCT 成像中始终显示出终板断裂：该研究揭示了在屈曲-压缩联合加载下，猪腰椎单元在循环加载和静态加载机制下的蠕变响应存在统计学意义上的显著差异。观察到的双相行为表明组织反应有不同的阶段，这表明负荷传递机制可能发生了转变。与静态加载相比，循环测试中的终板骨折表明损伤风险增加。这些发现强调了在计算模型中考虑加载条件以及为涉及脊柱重复加载的职业设计预防措施的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Biomedical Engineering 工程技术-工程：生物医学

CiteScore

7.50

自引率

15.80%

发文量

212

审稿时长

3 months

期刊介绍： Annals of Biomedical Engineering is an official journal of the Biomedical Engineering Society, publishing original articles in the major fields of bioengineering and biomedical engineering. The Annals is an interdisciplinary and international journal with the aim to highlight integrated approaches to the solutions of biological and biomedical problems.