{"title":"Epigenetics modification among vitrified oocytes and early embryos derived from them: a narrative review.","authors":"Mostafa Saeedinia, Jiayi Chen, Omid Kohandel Gargari, Kyana Jafarabady, Majid Zaki-Dizaji, Alireza Ghorbankhanloo, Zohreh Heidary","doi":"10.14715/cmb/2024.70.7.4","DOIUrl":null,"url":null,"abstract":"<p><p>Vitrification has important application in assisted reproductive technology (ART) and this technique has been widely used in the cryopreservation of oocytes and embryos. However, due to susceptibility of epigenetic modifications to environmental changes induced by cryopreservation procedures, there are concerns about the potential epigenetic consequences of oocyte and embryo vitrification. This review comprehensively summarized the effect of cryopreservation-especially the vitrification method in ART-on oocytes and embryos. Various studies have reported changes in different aspects of genomic status which directly affect the quality of fertilized embryos. The objective of this review is to assess existing literature on the epigenetic modifications that occur in vitrified oocytes and early embryos resulting from oocyte vitrification, including DNA modifications, RNA methylation, histone modification and microRNAs related to ART.</p>","PeriodicalId":9802,"journal":{"name":"Cellular and molecular biology","volume":"70 7","pages":"22-28"},"PeriodicalIF":1.5000,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cellular and molecular biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.14715/cmb/2024.70.7.4","RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Vitrification has important application in assisted reproductive technology (ART) and this technique has been widely used in the cryopreservation of oocytes and embryos. However, due to susceptibility of epigenetic modifications to environmental changes induced by cryopreservation procedures, there are concerns about the potential epigenetic consequences of oocyte and embryo vitrification. This review comprehensively summarized the effect of cryopreservation-especially the vitrification method in ART-on oocytes and embryos. Various studies have reported changes in different aspects of genomic status which directly affect the quality of fertilized embryos. The objective of this review is to assess existing literature on the epigenetic modifications that occur in vitrified oocytes and early embryos resulting from oocyte vitrification, including DNA modifications, RNA methylation, histone modification and microRNAs related to ART.
玻璃化技术在辅助生殖技术（ART）中有着重要的应用，该技术已被广泛用于卵母细胞和胚胎的冷冻保存。然而，由于表观遗传学易受冷冻程序引起的环境变化的影响，人们对卵母细胞和胚胎玻璃化的潜在表观遗传学后果表示担忧。本综述全面总结了冷冻保存--尤其是 ART 中的玻璃化方法--对卵母细胞和胚胎的影响。多项研究报告了基因组状态不同方面的变化，这些变化直接影响受精胚胎的质量。 本综述旨在评估有关卵母细胞玻璃化导致玻璃化卵母细胞和早期胚胎发生表观遗传学修饰的现有文献，包括与 ART 相关的 DNA 修饰、RNA 甲基化、组蛋白修饰和 microRNA。
期刊介绍：
Cellular and Molecular Biology publishes original articles, reviews, short communications, methods, meta-analysis notes, letters to editor and comments in the interdisciplinary science of Cellular and Molecular Biology linking and integrating molecular biology, biophysics, biochemistry, enzymology, physiology and biotechnology in a dynamic cell and tissue biology environment, applied to human, animals, plants tissues as well to microbial and viral cells. The journal Cellular and Molecular Biology is therefore open to intense interdisciplinary exchanges in medical, dental, veterinary, pharmacological, botanical and biological researches for the demonstration of these multiple links.
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