Effects of Propolis Consumption on Glycemic Indices and Liver Enzymes in Adults: A Grading of Recommendations Assessment, Development, and Valuation-assessed Systematic Review and Dose-Response Meta-analysis

IF 3.2 4区医学 Q2 PHARMACOLOGY & PHARMACY Clinical therapeutics Pub Date : 2024-09-01 DOI:10.1016/j.clinthera.2024.06.022

Shaghayegh Adeli MSc , Mahsa Maroofi MSc , Fatemeh Pourteymour Fard Tabrizi Ph.D , Beitullah Alipour Ph.D , Marzieh Heidari MSc , Mahdi Vajdi Ph.D , Mahdieh Abbasalizad-Farhangi Ph.D

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Abstract

Purpose

Even though various randomized controlled trials (RCTs) have assessed the effect of propolis on glycemic indices and liver enzyme concentrations in adults, results have been inconsistent, without conclusive evidence. This systematic review and meta-analysis of RCTs sought to evaluate the effects of propolis consumption on glycemic indices and liver enzymes, fasting blood glucose, insulin, homeostatic model assessment of insulin resistance, glycosylated hemoglobin, alanine transaminase, aspartate aminotransferase, and gamma-glutamyl transferase in adults.

Methods

Two independent researchers systematically searched PubMed, EMBASE, Scopus, Web of Science, and the Cochrane Library for English-language RCTs published up to April 2024. The results were generated through a random-effects model and presented as the weighted mean difference (WMD) with a 95% CI. The Cochrane Risk of Bias Tool for RCTs and Grading of Recommendations Assessment, Development, and Evaluation assessment were used to evaluate quality assessment and certainty of evidence.

Findings

A total of 21 RCTs were included. A pooled analysis of 24 trials reported that propolis consumption led to a significant reduction in fasting blood glucose (WMD, −9.75 mg/dL; 95% CI, −16.14 to −3.35), insulin (WMD, −1.64 µU/mL; 95% CI, −2.61 to −0.68), glycosylated hemoglobin (WMD, −0.46%; 95% CI, −0.71 to −0.21), homeostatic model assessment of insulin resistance (WMD, −0.54; 95% CI, −0.98 to −0.09), alanine transaminase (WMD, −2.60 IU/L; 95% CI, −4.58 to −0.61), and aspartate aminotransferase (WMD, −2.07 IU/L; 95% CI, −3.05 to −1.09). However, there were no significant effects on gamma-glutamyl transferase in comparison with the control group.

Implications

This meta-analysis has shown that propolis supplementation may have beneficial effects on glycemic indices and liver enzymes. Future high-quality, long-term RCTs are needed to confirm our results. ClinicalTrials.gov identifiers: CRD42024524763. (Clin Ther. 2024;46:XXX–XXX) © 2024 Elsevier HS Journals, Inc.

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食用蜂胶对成人血糖指数和肝酶的影响：建议分级评估、发展和估值系统综述与剂量反应荟萃分析》（A Grading of Recommendations Assessment, Development, and Valuation-assessed Systematic Review and Dose-Response Meta-analysis）。

目的：尽管各种随机对照试验（RCT）评估了蜂胶对成人血糖指数和肝酶浓度的影响，但结果并不一致，也没有确凿的证据。本系统综述和荟萃分析试图评估服用蜂胶对成人血糖指数和肝酶、空腹血糖、胰岛素、胰岛素抵抗同态模型评估、糖化血红蛋白、丙氨酸转氨酶、天冬氨酸转氨酶和γ-谷氨酰转移酶的影响：两位独立研究人员系统地检索了 PubMed、EMBASE、Scopus、Web of Science 和 Cochrane Library 中截至 2024 年 4 月发表的英文 RCT。研究结果通过随机效应模型生成，并以加权平均差（WMD）和 95% CI 的形式呈现。采用 Cochrane Risk of Bias Tool for RCTs 和 Grading of Recommendations Assessment, Development, and Evaluation 评估方法对证据的质量评估和确定性进行评价：共纳入了 21 项研究性试验。对24项试验的汇总分析表明，服用蜂胶可显著降低空腹血糖（WMD，-9.75 mg/dL；95% CI，-16.14 至 -3.35）、胰岛素（WMD，-1.64 µU/mL；95% CI，-2.61 至 -0.68）、糖化血红蛋白（WMD，-0.46%；95% CI，-0.71 至 -0.21）、胰岛素抵抗的稳态模型评估（WMD，-0.54；95% CI，-0.98 至 -0.09）、丙氨酸转氨酶（WMD，-2.60 IU/L；95% CI，-4.58 至 -0.61）和天冬氨酸转氨酶（WMD，-2.07 IU/L；95% CI，-3.05 至 -1.09）。然而，与对照组相比，对γ-谷氨酰转移酶没有明显影响：这项荟萃分析表明，补充蜂胶可能会对血糖指数和肝酶产生有益影响。未来还需要高质量的长期研究试验来证实我们的结果：CRD42024524763。(Clin Ther. 2024;46:XXX-XXX) © 2024 Elsevier HS Journals, Inc.

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来源期刊

Clinical therapeutics 医学-药学

CiteScore

6.00

自引率

3.10%

发文量

154

审稿时长

9 weeks

期刊介绍： Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in diagnostics, pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.