Rational use of gastroprotectants in cats: An evidence-based approach.

IF 1.9 2区农林科学 Q2 VETERINARY SCIENCES Journal of Feline Medicine and Surgery Pub Date : 2024-08-01 DOI:10.1177/1098612X241274235

Katie Tolbert, Eric Stubbs

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Abstract

Practical relevance: Acid-related disorders including esophagitis and gastroduodenal ulceration are uncommon in the cat. However, when they occur, they can have devastating consequences and require targeted intervention, including the use of gastroprotectants. Careful consideration of the causes of esophagitis and gastroduodenal ulceration can help the clinician to determine which gastroprotectant to use, and when to begin and end gastroprotective therapy.

Clinical challenges: Gastroprotectants remain one of the most misused classes of drugs in veterinary and human medicine. There are very few studies evaluating the efficacy of gastroprotective agents in cats. Furthermore, goals for the degree of gastric acid suppression are extrapolated from studies performed in dogs and humans.

Aims: This review provides a foundation for the logical approach to the choice of gastroprotectant as indicated by the disease process, and is aimed at all veterinarians who prescribe gastroprotectants for use in cats.

Evidence base: The guidance provided in this review is supported by current literature, including consensus opinion from the American College of Veterinary Internal Medicine. Gaps in evidence for use of gastroprotectants in cats are filled by extrapolations from studies performed in dogs and humans.

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猫胃保护剂的合理使用：循证方法。

实用性：与酸有关的疾病，包括食管炎和胃十二指肠溃疡，在猫中并不常见。但是，一旦发生，它们可能会造成严重后果，需要进行有针对性的干预，包括使用胃保护剂。仔细考虑食管炎和胃十二指肠溃疡的原因有助于临床医生确定使用哪种胃保护剂，以及何时开始和结束胃保护疗法：胃保护剂仍是兽医和人类医学中最易滥用的药物类别之一。评估胃保护剂对猫的疗效的研究很少。此外，胃酸抑制程度的目标都是从狗和人的研究中推断出来的。目的：本综述为根据疾病过程选择胃保护剂的逻辑方法提供了基础，其对象是所有为猫开胃保护剂处方的兽医：本综述提供的指导意见得到了当前文献的支持，包括美国兽医内科学院的共识意见。在猫科动物中使用胃保护剂的证据缺口由在狗和人类中进行的研究推断填补。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Feline Medicine and Surgery 农林科学-兽医学

CiteScore

3.90

自引率

17.60%

发文量

254

审稿时长

8-16 weeks

期刊介绍： JFMS is an international, peer-reviewed journal aimed at both practitioners and researchers with an interest in the clinical veterinary healthcare of domestic cats. The journal is published monthly in two formats: ‘Classic’ editions containing high-quality original papers on all aspects of feline medicine and surgery, including basic research relevant to clinical practice; and dedicated ‘Clinical Practice’ editions primarily containing opinionated review articles providing state-of-the-art information for feline clinicians, along with other relevant articles such as consensus guidelines.