{"title":"Exploring the Potential of Asl-us-Soos (Glycyrrhiza glabra L.) in the Treatment of Respiratory Diseases-An Ethnomedicinal and Pharmacological Review.","authors":"Fuzela Sherwani, Mohammad Nawab","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Asl-us-Soos (Glycyrrhiza glabra L.) has been used as a therapeutic agent in the treatment of respiratory, digestive, and neurological disorders since ancient times in Unani Medicine. Its therapeutic uses have been documented in Unani pharmacopeia, classical textbooks, and manuscripts based on experience in clinical practices. Asl-us-Soos (AS) and its compound preparations are recommended in the treatment of respiratory diseases such as Dhat al-Janb (pleurisy), Dhat al-Ri'a (pneumonia), Jamod us Sadr (pulmonary apoplexy), Diq al-Nafas (asthma), Sil (thiasis), and Diq (pulmonary tuberculosis).</p><p><strong>Objectives: </strong>This review aimed to provide insight into ethno-medicinal uses, pharmacological activities, and phytochemical profile of AS. The review also highlights the prospects in the development of potential drug molecules for various respiratory ailments.</p><p><strong>Methods: </strong>This review is based on a search of authentic Unani classical literature and major databases such as Science Direct, Medline (via PubMed), Google Scholar, Scopus, and Web of Science. The studies published between January 2001 and February 2022 were included in this study.</p><p><strong>Results: </strong>This review found that AS had medicinal uses in various respiratory disorders. Its roots are used as single drug and compound formulations for the treatment of dry cough, bronchial asthma, bronchitis, and pneumonia. In addition, AS contains active phytoconstituents such as glycyrrhizin (glycyrrhizic acid), isoliquiritigenin, glabridin, and licochalcone A. They have been extensively studied using in vitro and in vivo models and were found to exhibit pharmacological effects in pulmonary tuberculosis, pulmonary carcinoma, emphysema, bronchial asthma, pneumonia, and upper respiratory tract infections. Moreover, glycyrrhizin has been found to possess therapeutic potential against COVID-19.</p><p><strong>Conclusion: </strong>This review concludes that AS is a potent anti-tumor, anti-inflammatory, anti-microbial, anti-oxidant, expectorant, and antitussive drug. This plant could be an important source for the development of new drug compounds for various respiratory diseases.</p>","PeriodicalId":7571,"journal":{"name":"Alternative therapies in health and medicine","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alternative therapies in health and medicine","FirstCategoryId":"3","ListUrlMain":"","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Asl-us-Soos (Glycyrrhiza glabra L.) has been used as a therapeutic agent in the treatment of respiratory, digestive, and neurological disorders since ancient times in Unani Medicine. Its therapeutic uses have been documented in Unani pharmacopeia, classical textbooks, and manuscripts based on experience in clinical practices. Asl-us-Soos (AS) and its compound preparations are recommended in the treatment of respiratory diseases such as Dhat al-Janb (pleurisy), Dhat al-Ri'a (pneumonia), Jamod us Sadr (pulmonary apoplexy), Diq al-Nafas (asthma), Sil (thiasis), and Diq (pulmonary tuberculosis).
Objectives: This review aimed to provide insight into ethno-medicinal uses, pharmacological activities, and phytochemical profile of AS. The review also highlights the prospects in the development of potential drug molecules for various respiratory ailments.
Methods: This review is based on a search of authentic Unani classical literature and major databases such as Science Direct, Medline (via PubMed), Google Scholar, Scopus, and Web of Science. The studies published between January 2001 and February 2022 were included in this study.
Results: This review found that AS had medicinal uses in various respiratory disorders. Its roots are used as single drug and compound formulations for the treatment of dry cough, bronchial asthma, bronchitis, and pneumonia. In addition, AS contains active phytoconstituents such as glycyrrhizin (glycyrrhizic acid), isoliquiritigenin, glabridin, and licochalcone A. They have been extensively studied using in vitro and in vivo models and were found to exhibit pharmacological effects in pulmonary tuberculosis, pulmonary carcinoma, emphysema, bronchial asthma, pneumonia, and upper respiratory tract infections. Moreover, glycyrrhizin has been found to possess therapeutic potential against COVID-19.
Conclusion: This review concludes that AS is a potent anti-tumor, anti-inflammatory, anti-microbial, anti-oxidant, expectorant, and antitussive drug. This plant could be an important source for the development of new drug compounds for various respiratory diseases.
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Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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