Babesiosis in immunosuppressed hosts: pathogenesis, diagnosis and management.

IF 3.6 3区 医学 Q2 INFECTIOUS DISEASES Current Opinion in Infectious Diseases Pub Date : 2024-10-01 Epub Date: 2024-08-02 DOI:10.1097/QCO.0000000000001038
Howard M Heller
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Abstract

Purpose of review: This review provides the most recent evidence of the challenges that occur in the management of babesiosis in immunocompromised hosts.

Recent findings: The epidemiology of babesiosis is affected by climate change leading to increasing numbers of cases as well as increasing areas of endemicity. Immunosuppressed hosts, especially with asplenia or B-cell defects, are at high risk of having severe disease as well as persistent and relapsed infection. Resistance to the primary therapies azithromycin and atovaquone can develop leading to further challenges in treating persistent or relapsed disease in the immunocompromised host.

Summary: Babesiosis is likely to become a more frequent infectious complication in immunosuppressed hosts as the areas of endemicity expand. Reduced efficacy of standard therapies is likely to continue emerging so more effort needs to be placed on methods of assessing resistance in vitro and developing more reliable treatments for resistant infections.

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免疫抑制宿主的巴贝西亚原虫病:发病机制、诊断和管理。
综述的目的:本综述提供了最新的证据,说明了免疫力低下的宿主在处理巴贝西亚原虫病时所面临的挑战:巴贝西亚原虫病的流行病学受到气候变化的影响,导致病例数量增加,流行地区扩大。免疫抑制宿主,尤其是胰腺功能减退或 B 细胞缺陷的宿主,极有可能患上严重疾病以及持续感染和复发感染。对主要疗法阿奇霉素和阿托伐醌的抗药性可能会产生,从而给治疗免疫力低下宿主的持续或复发疾病带来更多挑战。标准疗法的疗效降低可能会继续出现,因此需要在体外抗药性评估方法和开发更可靠的抗药性感染治疗方法方面付出更多努力。
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来源期刊
CiteScore
6.70
自引率
2.60%
发文量
121
审稿时长
6-12 weeks
期刊介绍: This reader-friendly, bimonthly resource provides a powerful, broad-based perspective on the most important advances from throughout the world literature. Featuring renowned guest editors and focusing exclusively on two topics, every issue of Current Opinion in Infectious Disease delivers unvarnished, expert assessments of developments from the previous year. Insightful editorials and on-the-mark invited reviews cover key subjects such as HIV infection and AIDS; skin and soft tissue infections; respiratory infections; paediatric and neonatal infections; gastrointestinal infections; tropical and travel-associated diseases; and antimicrobial agents.
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