REVIVED BCIS-2: update and key learnings.

IF 2 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Current Opinion in Cardiology Pub Date : 2024-09-01 Epub Date: 2024-08-08 DOI:10.1097/HCO.0000000000001158

Tesfamariam Aklilu Betemariam, Holly Morgan, Divaka Perera

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Abstract

Purpose of review: This review summarises the shifting paradigms in the treatment of ischemic left ventricular dysfunction, spotlighting the revascularization for ischemic ventricular dysfunction-British cardiovascular intervention society-2 (REVIVED-BCIS2) trial results and its impact on key therapeutic goals: survival, left ventricular function, arrhythmia prevention, quality of life and viability testing.

Recent findings: The REVIVED-BCIS2 trial, and its subsequent sub studies highlighted that (PCI) does not provide additional benefits to optimal medical therapy in terms of improving survival, left ventricular (LV) function, arrhythmic risk or quality of life. Additionally, viability testing did not differentiate patients who could benefit from PCI, although scar burden was found to be a significant predictor of outcome in these patients.

Summary: The outcomes of REVIVED have challenged multiple existing beliefs in the field of ischaemic left ventricular dysfunction management, emphasising the importance of investigating evidence free areas in our practice. Future work, including the STICH3 international consortium of trials, aims to answer some of the remaining unanswered questions.

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经修订的 BCIS-2：最新情况和主要经验教训。

综述目的：本综述总结了缺血性左心室功能障碍治疗范式的转变，重点介绍了缺血性心室功能障碍血管重建-英国心血管介入学会-2（REVIVED-BCIS2）试验结果及其对主要治疗目标的影响：生存率、左心室功能、心律失常预防、生活质量和存活率测试：REVIVED-BCIS2试验及其后续子研究强调，在改善生存率、左心室（LV）功能、心律失常风险或生活质量方面，PCI并不能提供优于最佳药物治疗的额外益处。总结：REVIVED 的研究结果对缺血性左心室功能障碍治疗领域现有的多种观点提出了挑战，强调了在实践中研究无证据领域的重要性。未来的工作，包括 STICH3 国际试验联盟，旨在回答一些余下的未解之谜。

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来源期刊

Current Opinion in Cardiology 医学-心血管系统

CiteScore

4.20

自引率

4.30%

发文量

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Cardiology is a bimonthly publication offering a unique and wide ranging perspective on the key developments in the field. Each issue features hand-picked review articles from our team of expert editors. With fourteen disciplines published across the year – including arrhythmias, molecular genetics, HDL cholesterol and clinical trials – every issue also contains annotated reference detailing the merits of the most important papers.