A Cell Observatory to reveal the subcellular foundations of life

IF 32.1 1区生物学 Q1 BIOCHEMICAL RESEARCH METHODS Nature Methods Pub Date : 2024-08-07 DOI:10.1038/s41592-024-02379-3

Eric Betzig

引用次数: 0

Abstract

Imaging the 4D choreography of subcellular events in living multicellular organisms at high spatiotemporal resolution could reveal life’s fundamental principles. Yet extracting these principles from petabyte-scale image data requires fusing advanced light microscopy and cutting-edge machine learning models with biological insight and expertise.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

细胞观测站揭示生命的亚细胞基础。

以高时空分辨率成像多细胞生物亚细胞事件的4D编排可以揭示生命的基本原理。然而，从pb级图像数据中提取这些原理需要将先进的光学显微镜和尖端的机器学习模型与生物学洞察力和专业知识融合在一起。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Nature Methods 生物-生化研究方法

CiteScore

58.70

自引率

1.70%

发文量

326

审稿时长

1 months

期刊介绍： Nature Methods is a monthly journal that focuses on publishing innovative methods and substantial enhancements to fundamental life sciences research techniques. Geared towards a diverse, interdisciplinary readership of researchers in academia and industry engaged in laboratory work, the journal offers new tools for research and emphasizes the immediate practical significance of the featured work. It publishes primary research papers and reviews recent technical and methodological advancements, with a particular interest in primary methods papers relevant to the biological and biomedical sciences. This includes methods rooted in chemistry with practical applications for studying biological problems.

期刊最新文献

Orthrus: toward evolutionary and functional RNA foundation models. Decoding the language of messenger RNA. Scientists who decide to pick up and move. A series of spontaneously blinking dyes for super-resolution microscopy. Designer indicators for two-photon recording of subthreshold voltage dynamics.