Prognostic value of 18F-FDG PET/CT in postoperative recurrence of retroperitoneal liposarcoma: a single-center retrospective study.

IF 1.3 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Nuclear Medicine Communications Pub Date : 2024-08-08 DOI:10.1097/MNM.0000000000001886
Juntao Lang, Wenshuai Liu, Guobing Liu, Siwei Liu, Yiqiu Zhang
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Abstract

Objective: Recurrence is the leading cause of tumor-related death in retroperitoneal liposarcoma (RPLPS). Variant subtypes of RPLPS determine different recurrence 18F]-fluoro-2-deoxy-D-glucose (18F-FDG) PET/computed tomography (PET/CT). This study analyzed the characteristics of different histologic subtypes of 18F-FDG PET/CT and their associations with recurrence and prognosis.

Methods: Clinical-pathological information, 18F-FDG PET/CT data, recurrence, and progression-free survivals (PFS) of 83 patients with RPLPS were collected. Maximum and peak standardized uptake values (SUVmax and SUVpeak, respectively) and mean CT value (CTmean) of tumors were measured and correlated with histologic subtype. The predictability of SUVmax, SUVpeak, and CTmean for the histologic subtype was evaluated using receiver operating characteristics (ROC) max and SUVpeak for recurrence. Kaplan-Meier analysis was performed to max and SUVpeak were risk factors for recurrence.

Results: Studied patients with different types of liposarcomas. Dedifferentiated liposarcomas (DDLPS) had higher SUVmax and SUVpeak than well-differentiated (WDLPS) and myxoid/round cell (MLPS) types. WDLPS had lower CTmean values compared to MLPS and DDLPS. Using ROC curves, determined cut-off values for SUVmax (5.1) to differentiate DDLPS, SUVpeak (3.0) for WDLPS, and CTmean (12.3 Hu) for WDLPS. These cut-offs were found to be best for predicting recurrence. Kaplan-Meier analysis showed that histologic subtype, SUVmax, and SUVpeak were all linked to recurrence-free survival.

Conclusions: The use of SUV and CT features on 18F-FDG PET/CT imaging may increase confidence in subtype diagnosis. Patients with SUVmax > 5.1 or SUVpeak > 3.0 suggest a poor prognosis.

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18F-FDG PET/CT 在腹膜后脂肪肉瘤术后复发中的预后价值:一项单中心回顾性研究。
目的:复发是腹膜后脂肪肉瘤(RPLPS)中肿瘤相关死亡的主要原因。RPLPS的不同亚型决定了18F]-氟-2-脱氧-D-葡萄糖(18F-FDG)PET/计算机断层扫描(PET/CT)的不同复发率。本研究分析了 18F-FDG PET/CT 不同组织学亚型的特征及其与复发和预后的关系:方法:收集了83例RPLPS患者的临床病理信息、18F-FDG PET/CT数据、复发率和无进展生存期(PFS)。测量了肿瘤的最大和峰值标准化摄取值(分别为SUVmax和SUVpeak)以及平均CT值(CTmean),并将其与组织学亚型相关联。利用接收器操作特征(ROC)最大值和SUVpeak值对复发的预测性评估了SUVmax、SUVpeak和CTmean对组织学亚型的预测性。对复发的风险因素最大值和SUVpeak进行了Kaplan-Meier分析:研究了不同类型的脂肪肉瘤患者。与分化良好型(WDLPS)和类肉瘤/圆形细胞型(MLPS)相比,未分化脂肪肉瘤(DDLPS)的SUVmax和SUVpeak更高。与 MLPS 和 DDLPS 相比,WDLPS 的 CTmean 值更低。利用 ROC 曲线确定了区分 DDLPS 的 SUVmax 临界值(5.1)、区分 WDLPS 的 SUVpeak 临界值(3.0)和区分 WDLPS 的 CTmean 临界值(12.3 Hu)。这些临界值被认为是预测复发的最佳值。Kaplan-Meier分析显示,组织学亚型、SUVmax和SUVpeak均与无复发生存率相关:结论:使用18F-FDG PET/CT成像的SUV和CT特征可增加亚型诊断的可信度。SUVmax>5.1或SUVpeak>3.0的患者预后较差。
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来源期刊
CiteScore
2.20
自引率
6.70%
发文量
212
审稿时长
3-8 weeks
期刊介绍: Nuclear Medicine Communications, the official journal of the British Nuclear Medicine Society, is a rapid communications journal covering nuclear medicine and molecular imaging with radionuclides, and the basic supporting sciences. As well as clinical research and commentary, manuscripts describing research on preclinical and basic sciences (radiochemistry, radiopharmacy, radiobiology, radiopharmacology, medical physics, computing and engineering, and technical and nursing professions involved in delivering nuclear medicine services) are welcomed, as the journal is intended to be of interest internationally to all members of the many medical and non-medical disciplines involved in nuclear medicine. In addition to papers reporting original studies, frankly written editorials and topical reviews are a regular feature of the journal.
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