Vascular and immune interactions in islets transplantation and 3D islet models

IF 3.7 2区 生物学 Q2 CELL BIOLOGY Current Opinion in Genetics & Development Pub Date : 2024-08-06 DOI:10.1016/j.gde.2024.102237
Adriana Migliorini , M Cristina Nostro
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Abstract

The aim of regenerative medicine is to restore specific functions to damaged cells or tissues. A crucial aspect of success lies in effectively reintegrating these cells or tissues within the recipient organism. This is particularly pertinent for diabetes, where islet function relies on the close connection of beta cells to the bloodstream for glucose sensing and insulin release. Central to this approach is the need to establish a fast connection with the host’s vascular system. In this review, we explore the intricate relationships between endocrine, vascular, and immune cell interactions in transplantation outcomes. We also delve into recent strategies aimed at enhancing engraftment, along with the utilization of in vitro platforms to model cellular interactions.

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胰岛移植和三维胰岛模型中的血管与免疫相互作用。
再生医学的目的是恢复受损细胞或组织的特定功能。成功的关键在于有效地将这些细胞或组织重新整合到受体机体内。这一点对糖尿病患者尤为重要,因为糖尿病患者的胰岛功能依赖于β细胞与血液的密切联系,以感知葡萄糖并释放胰岛素。这种方法的核心是需要与宿主的血管系统建立快速连接。在这篇综述中,我们探讨了移植结果中内分泌、血管和免疫细胞相互作用之间错综复杂的关系。我们还深入探讨了旨在增强移植效果的最新策略,以及利用体外平台模拟细胞相互作用的方法。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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