Jung Hwan Shin, Hui-Jun Yang, Jong Hyun Ahn, Sungyang Jo, Seok Jong Chung, Jee-Young Lee, Hyun Sook Kim, Manho Kim
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引用次数: 0
Abstract
Huntington's disease (HD) is a neurodegenerative disorder with a significant impact on patients' quality of life, characterized by motor, behavioral, and cognitive impairments. This evidence-based review, conducted by the Korean Huntington Disease Society (KHDS) task force, systematically examines current pharmacological and non-pharmacological interventions for symptomatic management of HD. Following PRISMA guidelines, databases were searched for studies up to August 2022, focusing on 23 symptoms across four domains: motor, neuropsychological, cognition, and others. This review provides a comprehensive and systematic approach to the management of HD, highlighting the need for more high-quality clinical trials to develop robust evidence-based guidelines.
亨廷顿氏病（Huntington's disease，HD）是一种神经退行性疾病，以运动、行为和认知障碍为特征，严重影响患者的生活质量。本循证综述由韩国亨廷顿氏病协会（KHDS）特别工作组进行，系统地研究了目前用于治疗 HD 症状的药物和非药物干预措施。根据PRISMA指南，数据库检索了截至2022年8月的研究，重点关注运动、神经心理、认知和其他四个领域的23种症状。本综述为 HD 的治疗提供了一种全面而系统的方法，强调需要更多高质量的临床试验来制定强有力的循证指南。
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