Jung Hwan Shin, Hui-Jun Yang, Jong Hyun Ahn, Sungyang Jo, Seok Jong Chung, Jee-Young Lee, Hyun Sook Kim, Manho Kim
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引用次数: 0
Abstract
Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, behavioral, and cognitive impairments and significant impacts on patient quality of life. This evidence-based review, conducted by the Korean Huntington Disease Society task force, systematically examines current pharmacological and nonpharmacological interventions for symptomatic management of HD. Following PRISMA guidelines, databases were searched for studies up to August 2022 that focused on 23 symptoms across four domains: motor, neuropsychological, cognition, and others. This review provides a comprehensive and systematic approach to the management of HD, highlighting the need for more high-quality clinical trials to develop robust evidence-based guidelines.
亨廷顿氏病（Huntington's disease，HD）是一种神经退行性疾病，以运动、行为和认知障碍为特征，严重影响患者的生活质量。本循证综述由韩国亨廷顿氏病协会（KHDS）特别工作组进行，系统地研究了目前用于治疗 HD 症状的药物和非药物干预措施。根据PRISMA指南，数据库检索了截至2022年8月的研究，重点关注运动、神经心理、认知和其他四个领域的23种症状。本综述为 HD 的治疗提供了一种全面而系统的方法，强调需要更多高质量的临床试验来制定强有力的循证指南。
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