Non-invasive assessment of hepatic fibrosis among patients with chronic hepatitis B virus infection in three tertiary hospitals in Nigeria.

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL SAGE Open Medicine Pub Date : 2024-08-07 eCollection Date: 2024-01-01 DOI:10.1177/20503121241264313
Oguntoye Oluwatosin Oluwagbenga, Abdulkareem Lukman Olaitan, Umoru Benedict Ihiovi, Osasona Oluwadamilola Gideon, Ifeorah Ijeoma Maryjoy, Ariyo Olumuyiwa Elijah, Jegede Oluwatosin Samson, Oguntoye Oluwafunmilayo Adenike
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Abstract

Objective: This study aimed to assess hepatic fibrosis, using noninvasive tests, among patients with chronic hepatitis B virus infection in Nigeria.

Methods: The study was a retrospective cross-sectional, hospital-based, multicentered study. The data of adult Nigerians who were aged 18 years and above who had been diagnosed with chronic hepatitis B infection and were not on treatment were extracted from three tertiary health institutions across Nigeria. Sociodemographic and relevant clinical data were obtained from the case notes of the patients. Fibrosis-4 and aspartate aminotransferase platelet ratio index scores were calculated to determine the presence and severity of liver fibrosis in the patients. The data obtained were analyzed using Statistical Package for the Social Sciences (version 25.0). A p-value of less than 0.05 was considered as statistically significant.

Results: The data of a total of 234 patients were extracted for this study from across 3 tertiary hospitals in Nigeria. There were 132 (56.4%) males and 102 (43.6%) females in a ratio of 1.29:1 with a mean age of 37.92 ± 12.34 years. The fibrosis-4 score of the patients showed that 62.8% had "Normal/Mild Fibrosis," 25.6% had "Moderate Fibrosis," and 11.5% had "Severe Fibrosis/Cirrhosis." The aspartate aminotransferase platelet ratio index score of the patients showed that 64.1% had "No Fibrosis," 20.9% had "Mild Fibrosis," 6.4% had "Moderate Fibrosis," and 8.5% had "Severe Fibrosis/Cirrhosis." The median fibrosis-4 score of the patients was 1.18 (0.77-1.74), while the median aspartate aminotransferase platelet ratio index score was 0.40 (0.26-0.69). Liver ultrasonography detected cirrhosis in 8.5% of the patients. All the patients were not yet on treatment for hepatitis B infection.

Conclusion: The prevalence of hepatic fibrosis is high among patients with chronic hepatitis B virus infection in Nigeria and a large number of these patients were not yet on therapy. Noninvasive assessment of hepatic fibrosis should be considered as a critical part of the work-up of patients with chronic hepatitis B infection.

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尼日利亚三家三级医院慢性乙型肝炎病毒感染患者肝纤维化的非侵入性评估。
目的:本研究旨在通过无创检测评估尼日利亚慢性乙型肝炎病毒感染患者的肝纤维化情况:本研究旨在利用无创检测评估尼日利亚慢性乙型肝炎病毒感染患者的肝纤维化情况:本研究是一项以医院为基础的多中心回顾性横断面研究。研究人员从尼日利亚的三家三级医疗机构中提取了 18 岁及以上被诊断为慢性乙型肝炎感染且未接受治疗的尼日利亚成年人的数据。社会人口学和相关临床数据来自患者的病例记录。通过计算纤维化-4 和天门冬氨酸氨基转移酶血小板比率指数得分,确定患者是否存在肝纤维化及其严重程度。获得的数据使用社会科学统计软件包(25.0 版)进行分析。P值小于0.05为具有统计学意义:本研究从尼日利亚 3 家三级医院共提取了 234 名患者的数据。其中男性 132 人(56.4%),女性 102 人(43.6%),男女比例为 1.29:1,平均年龄为 37.92 ± 12.34 岁。患者的纤维化-4评分显示,62.8%为 "正常/轻度纤维化",25.6%为 "中度纤维化",11.5%为 "重度纤维化/肝硬化"。患者的天冬氨酸氨基转移酶血小板比率指数得分显示,64.1%的患者 "无纤维化",20.9%的患者 "轻度纤维化",6.4%的患者 "中度纤维化",8.5%的患者 "重度纤维化/肝硬化"。患者的纤维化-4 评分中位数为 1.18(0.77-1.74),天门冬氨酸氨基转移酶血小板比率指数评分中位数为 0.40(0.26-0.69)。8.5%的患者通过肝脏超声波检查发现肝硬化。所有患者均未接受过乙型肝炎感染治疗:结论:尼日利亚慢性乙型肝炎病毒感染患者的肝纤维化发病率很高,其中很多患者尚未接受治疗。肝纤维化的无创评估应被视为慢性乙型肝炎感染患者检查的重要组成部分。
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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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