A case of response to combination treatment with TSA-DC-CTL immunotherapy and osimertinib in EGFR mutated advanced lung adenocarcinoma

IF 27.7 1区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Cancer Pub Date : 2024-08-09 DOI:10.1186/s12943-024-02070-3

Zhiyi Han, Tao Li, Heng Zhang, Kai Liang, Mingcong You, Mengdi Xu, Fan Bai, Tongmei Zhang

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Abstract

This study details a case of a patient with advanced lung adenocarcinoma harboring an exon 19 deletion in the EGFR gene. A 46-year-old female patient was diagnosed with stage IVb left lung adenocarcinoma, with multiple bone and lymph node metastases. Following the identification of tumor-specific antigen peptides, the patient received a combination treatment of immunotherapy (TSA-DC-CTL) and oral osimertinib. Peripheral blood circulating immune cells and circulating tumor cells (CTCs) were monitored before and after treatment. PET-CT and CT scans were used to assess the tumor response to treatment. A significant increase in total lymphocyte percentage and decrease in the number of CTCs in the patient was observed. Imaging studies showed a notable reduction in tumor metastases. This report demonstrates the safety and efficacy of TSA-DC-CTL cell immunotherapy combined with osimertinib in the treatment of a patient with advanced lung adenocarcinoma with an EGFR exon 19 deletions. This study describes a promising new treatment option for patients with advanced lung cancer with EGFR mutations.

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一例表皮生长因子受体突变晚期肺腺癌患者对TSA-DC-CTL免疫疗法和奥希替尼联合治疗的应答病例

本研究详细介绍了一例表皮生长因子受体基因第19外显子缺失的晚期肺腺癌患者。一名 46 岁的女性患者被诊断为左肺腺癌 IVb 期，并伴有多处骨和淋巴结转移。在鉴定出肿瘤特异性抗原肽后，患者接受了免疫疗法（TSA-DC-CTL）和口服奥希替尼的联合治疗。治疗前后对外周血循环免疫细胞和循环肿瘤细胞（CTC）进行了监测。PET-CT 和 CT 扫描用于评估肿瘤对治疗的反应。结果显示，患者的总淋巴细胞比例明显增加，CTC数量明显减少。影像学研究显示肿瘤转移明显减少。本报告展示了 TSA-DC-CTL 细胞免疫疗法联合奥希替尼治疗表皮生长因子受体外显子 19 缺失的晚期肺腺癌患者的安全性和有效性。这项研究为表皮生长因子受体（EGFR）突变的晚期肺癌患者提供了一种前景广阔的新治疗方案。

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来源期刊

Molecular Cancer 医学-生化与分子生物学

CiteScore

54.90

自引率

2.70%

发文量

224

审稿时长

2 months

期刊介绍： Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.