Chaolu Meng, Yue Pei, Yongbo Bu, Qing Liu, Qun Li, Quan Zou, Ying Zhang
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引用次数: 0
Abstract
The purpose of feature selection in protein sequence recognition problems is to select the optimal feature set and use it as training input for classifiers and discover key sequence features of specific proteins. In the feature selection process, relevant features associated with the target task will be retained, and irrelevant and redundant features will be removed. Therefore, in an ideal state, a feature combination with smaller feature dimensions and higher performance indicators is desired. This paper proposes an algorithm called IIFS2.0 based on the cache elimination strategy, which takes the local optimal combination of cached feature subsets as a breakthrough point. It searches for a new feature combination method through the cache elimination strategy to avoid the drawbacks of human factors and excessive reliance on feature sorting results. We validated and analyzed its effectiveness on the protein dataset, demonstrating that IIFS2.0 significantly reduces the dimensionality of feature combinations while also improving various evaluation indicators. In addition, we provide IIFS2.0 on https://112.124.26.17:8006/ for researchers to use.
期刊介绍:
Journal of Molecular Biology (JMB) provides high quality, comprehensive and broad coverage in all areas of molecular biology. The journal publishes original scientific research papers that provide mechanistic and functional insights and report a significant advance to the field. The journal encourages the submission of multidisciplinary studies that use complementary experimental and computational approaches to address challenging biological questions.
Research areas include but are not limited to: Biomolecular interactions, signaling networks, systems biology; Cell cycle, cell growth, cell differentiation; Cell death, autophagy; Cell signaling and regulation; Chemical biology; Computational biology, in combination with experimental studies; DNA replication, repair, and recombination; Development, regenerative biology, mechanistic and functional studies of stem cells; Epigenetics, chromatin structure and function; Gene expression; Membrane processes, cell surface proteins and cell-cell interactions; Methodological advances, both experimental and theoretical, including databases; Microbiology, virology, and interactions with the host or environment; Microbiota mechanistic and functional studies; Nuclear organization; Post-translational modifications, proteomics; Processing and function of biologically important macromolecules and complexes; Molecular basis of disease; RNA processing, structure and functions of non-coding RNAs, transcription; Sorting, spatiotemporal organization, trafficking; Structural biology; Synthetic biology; Translation, protein folding, chaperones, protein degradation and quality control.